ID   RNMT_MYCLE              Reviewed;         229 AA.
AC   Q9CD89;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Rhamnosyl O-methyltransferase;
DE            EC=2.1.1.-;
DE   Flags: Precursor;
GN   OrderedLocusNames=ML0127;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Catalyzes the O-methylation of the hydroxyl group located on
CC       C-2 of the first rhamnosyl residue linked to the phenolic group of
CC       glycosylated phenolphthiocerol dimycocerosates (PGL) and p-
CC       hydroxybenzoic acid derivatives (p-HBAD). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the rhamnosyl O-methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AL583917; CAC29635.1; -; Genomic_DNA.
DR   PIR; G86924; G86924.
DR   RefSeq; NP_301221.1; NC_002677.1.
DR   RefSeq; WP_010907546.1; NC_002677.1.
DR   AlphaFoldDB; Q9CD89; -.
DR   SMR; Q9CD89; -.
DR   STRING; 272631.ML0127; -.
DR   EnsemblBacteria; CAC29635; CAC29635; CAC29635.
DR   KEGG; mle:ML0127; -.
DR   PATRIC; fig|272631.5.peg.195; -.
DR   Leproma; ML0127; -.
DR   eggNOG; COG3510; Bacteria.
DR   HOGENOM; CLU_063868_0_0_11; -.
DR   OMA; MIQGSSI; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR007072; Rhamnosyl_O-MeTrfase_CmcI.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04989; CmcI; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis; Lipid metabolism; Methyltransferase;
KW   Reference proteome; Signal; Transferase.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..229
FT                   /note="Rhamnosyl O-methyltransferase"
FT                   /id="PRO_0000305180"
SQ   SEQUENCE   229 AA;  26203 MW;  F3D101FC7A9724F6 CRC64;
     MERVRQMFSC VSGMIYRPTD SIAEEYHKWY YGNFVWNTTT WMGIKCLKSV SDMWNYQEIL
     IELEPSLVIE FGSRFGGSAL FFANVMMHIG QPFKVLSVDI SHKDLDPAAR QPDILFIESP
     STAPAIAEQI RRLKNEYPGK IFAILDSDHS MKQVLAEMKL LQPLLTAGDY LVVEDSNLNG
     HPVLPRFGAG PYEAIEAYER EFPGDYEHDV AREKKFGFTF ATNGFLIRK