RNMT_MYCTA
ID RNMT_MYCTA Reviewed; 245 AA.
AC A5U6W7;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Rhamnosyl O-methyltransferase;
DE EC=2.1.1.-;
DE Flags: Precursor;
GN OrderedLocusNames=MRA_2986;
OS Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=419947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25177 / H37Ra;
RX PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA Wang H., Wang S., Zhao G., Zhang Y.;
RT "Genetic basis of virulence attenuation revealed by comparative genomic
RT analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL PLoS ONE 3:E2375-E2375(2008).
CC -!- FUNCTION: Catalyzes the O-methylation of the hydroxyl group located on
CC C-2 of the first rhamnosyl residue linked to the phenolic group of
CC glycosylated phenolphthiocerol dimycocerosates (PGL) and p-
CC hydroxybenzoic acid derivatives (p-HBAD). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the rhamnosyl O-methyltransferase family.
CC {ECO:0000305}.
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DR EMBL; CP000611; ABQ74767.1; -; Genomic_DNA.
DR RefSeq; WP_003414919.1; NZ_CP016972.1.
DR AlphaFoldDB; A5U6W7; -.
DR SMR; A5U6W7; -.
DR STRING; 419947.MRA_2986; -.
DR EnsemblBacteria; ABQ74767; ABQ74767; MRA_2986.
DR GeneID; 45426947; -.
DR KEGG; mra:MRA_2986; -.
DR eggNOG; COG3510; Bacteria.
DR HOGENOM; CLU_063868_0_0_11; -.
DR OMA; MIQGSSI; -.
DR OrthoDB; 1831745at2; -.
DR Proteomes; UP000001988; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR007072; Rhamnosyl_O-MeTrfase_CmcI.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF04989; CmcI; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis; Lipid metabolism; Methyltransferase; Signal;
KW Transferase.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..245
FT /note="Rhamnosyl O-methyltransferase"
FT /id="PRO_0000305182"
SQ SEQUENCE 245 AA; 27845 MW; 0B2540CBB532E3A6 CRC64;
MGLVWRSRTS LVGQLIGLVR LVASFAAQLF YRPSDAVAEE YHKWYYGNLV WTKTTYMGIN
CWKSVSDMWN YQEILSELQP SLVIEFGTRY GGSAVYFANI MRQIGQPFKV LTVDNSHKAL
DPRARREPDV LFVESSSTDP AIAEQIQRLK NEYPGKIFAI LDSDHSMNHV LAEMKLLRPL
LSAGDYLVVE DSNINGHPVL PGFGPGPYEA IEAYEDEFPN DYKHDAEREN KFGWTSAPNG
FLIRN