ID   RNMT_MYCTO              Reviewed;         245 AA.
AC   P9WIM4; L0TDW5; O08024; Q50457; Q798M6; Q7D6D0;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Rhamnosyl O-methyltransferase;
DE            EC=2.1.1.-;
DE   Flags: Precursor;
GN   OrderedLocusNames=MT3035;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Catalyzes the O-methylation of the hydroxyl group located on
CC       C-2 of the first rhamnosyl residue linked to the phenolic group of
CC       glycosylated phenolphthiocerol dimycocerosates (PGL) and p-
CC       hydroxybenzoic acid derivatives (p-HBAD). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the rhamnosyl O-methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK47361.1; -; Genomic_DNA.
DR   PIR; D70670; D70670.
DR   RefSeq; WP_003414919.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WIM4; -.
DR   SMR; P9WIM4; -.
DR   EnsemblBacteria; AAK47361; AAK47361; MT3035.
DR   GeneID; 45426947; -.
DR   KEGG; mtc:MT3035; -.
DR   PATRIC; fig|83331.31.peg.3277; -.
DR   HOGENOM; CLU_063868_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR007072; Rhamnosyl_O-MeTrfase_CmcI.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04989; CmcI; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis; Lipid metabolism; Methyltransferase; Signal;
KW   Transferase.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000255"
FT   CHAIN           39..245
FT                   /note="Rhamnosyl O-methyltransferase"
FT                   /id="PRO_0000427980"
SQ   SEQUENCE   245 AA;  27845 MW;  0B2540CBB532E3A6 CRC64;
     MGLVWRSRTS LVGQLIGLVR LVASFAAQLF YRPSDAVAEE YHKWYYGNLV WTKTTYMGIN
     CWKSVSDMWN YQEILSELQP SLVIEFGTRY GGSAVYFANI MRQIGQPFKV LTVDNSHKAL
     DPRARREPDV LFVESSSTDP AIAEQIQRLK NEYPGKIFAI LDSDHSMNHV LAEMKLLRPL
     LSAGDYLVVE DSNINGHPVL PGFGPGPYEA IEAYEDEFPN DYKHDAEREN KFGWTSAPNG
     FLIRN