RNO_DROME
ID RNO_DROME Reviewed; 3241 AA.
AC Q7YZH1; M9NDD8; Q9W0U2;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=PHD finger protein rhinoceros;
GN Name=rno; ORFNames=CG7036;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=14704181; DOI=10.1093/genetics/165.4.1993;
RA Voas M.G., Rebay I.;
RT "The novel plant homeodomain protein rhinoceros antagonizes Ras signaling
RT in the Drosophila eye.";
RL Genetics 165:1993-2006(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1346; SER-1352; THR-1364;
RP THR-1456; SER-2880; SER-2881; SER-3104 AND SER-3110, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: May function as a negative regulator of the EGFR/Ras/MAPK
CC signaling pathway during eye development.
CC {ECO:0000269|PubMed:14704181}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14704181}.
CC -!- SIMILARITY: Belongs to the JADE family. {ECO:0000305}.
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DR EMBL; AY321364; AAP84718.1; -; mRNA.
DR EMBL; AE014296; AAF47343.2; -; Genomic_DNA.
DR EMBL; AE014296; AAS64921.1; -; Genomic_DNA.
DR EMBL; AE014296; AFH04199.1; -; Genomic_DNA.
DR RefSeq; NP_001246528.1; NM_001259599.2.
DR RefSeq; NP_612007.2; NM_138163.2.
DR RefSeq; NP_995944.1; NM_206222.3.
DR SMR; Q7YZH1; -.
DR BioGRID; 63591; 5.
DR IntAct; Q7YZH1; 5.
DR STRING; 7227.FBpp0072431; -.
DR iPTMnet; Q7YZH1; -.
DR PaxDb; Q7YZH1; -.
DR PRIDE; Q7YZH1; -.
DR EnsemblMetazoa; FBtr0072532; FBpp0072431; FBgn0035106.
DR EnsemblMetazoa; FBtr0305548; FBpp0293999; FBgn0035106.
DR EnsemblMetazoa; FBtr0305549; FBpp0294000; FBgn0035106.
DR GeneID; 38027; -.
DR KEGG; dme:Dmel_CG7036; -.
DR UCSC; CG7036-RA; d. melanogaster.
DR CTD; 38027; -.
DR FlyBase; FBgn0035106; rno.
DR VEuPathDB; VectorBase:FBgn0035106; -.
DR eggNOG; KOG0954; Eukaryota.
DR GeneTree; ENSGT00940000158722; -.
DR HOGENOM; CLU_225483_0_0_1; -.
DR InParanoid; Q7YZH1; -.
DR OMA; KYDPQTH; -.
DR OrthoDB; 566217at2759; -.
DR PhylomeDB; Q7YZH1; -.
DR SignaLink; Q7YZH1; -.
DR BioGRID-ORCS; 38027; 0 hits in 3 CRISPR screens.
DR ChiTaRS; rno; fly.
DR GenomeRNAi; 38027; -.
DR PRO; PR:Q7YZH1; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035106; Expressed in brain and 20 other tissues.
DR ExpressionAtlas; Q7YZH1; baseline and differential.
DR Genevisible; Q7YZH1; DM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042051; P:compound eye photoreceptor development; IMP:UniProtKB.
DR GO; GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF10513; EPL1; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Developmental protein; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..3241
FT /note="PHD finger protein rhinoceros"
FT /id="PRO_0000253537"
FT ZN_FING 312..362
FT /note="PHD-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT ZN_FING 364..398
FT /note="C2HC pre-PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT ZN_FING 422..481
FT /note="PHD-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..1266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1279..1483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1500..1613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1632..1746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2037..2061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2124..2148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2203..2227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2346..2454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2598..2629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2667..2691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2768..2811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2832..2911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2964..3015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3042..3169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3184..3241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1741..1770
FT /evidence="ECO:0000255"
FT COILED 1893..1925
FT /evidence="ECO:0000255"
FT COMPBIAS 20..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1060
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1221..1243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1378..1424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1459..1483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1501..1544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1545..1565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1567..1599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1730..1746
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2352..2388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2389..2408
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2598..2613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2785..2811
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2845..2865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2872..2891
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3111..3135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3152..3169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3184..3223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1346
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1352
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1364
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1456
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2880
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2881
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3104
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3110
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 3241 AA; 347626 MW; E3F3B62370D0F403 CRC64;
MSQRGKRGNQ QHHQSHHPPP QQHQRKDVEP QPPPTKRRKG RPPNGATTAA VAEVTGSGPA
TGSERVPVLP LCKSKHEEPG AEAGGGGQGR AAAGATSTSK SKSTKLAKSA SKCKSQGASS
SSSWQARSVA DIKMSSIYNR SSTEAPAELY RKDLISAMKL PDSEPLANYE YLIVTDPWKQ
EWEKGVQVPV NPDSLPEPCV YVLPEPVVSP AHDFKLPKNR YLRITKDEHY SPDLHYLTNV
VALAENTCAY DIDPIDEAWL RLYNSDRAQC GAFPINATQF ERVIEELEVR CWEQIQVILK
LEEGLGIEFD ENVICDVCRS PDSEEANEMV FCDNCNICVH QACYGITAIP SGQWLCRTCS
MGIKPDCVLC PNKGGAMKSN KSGKHWAHVS CALWIPEVSI GCVDRMEPIT KISSIPQSRW
SLICVLCRKR VGSCIQCSVK PCKTAYHVTC AFQHGLEMRA IIEEGNAEDG VKLRSYCQKH
SMSKGKKENA GSHGGGSASV ASAMQKANRY GSGAGGGADD GNNACGTTGE DPRRRKNHRK
TELTSEERNQ ARAQRLQEVE AEFDKHVNFN DISCHLFDVD DDAIVAIYNY WKLKRKSRHN
RELIPPKSED VEMIARKQEQ QDMENHKLVV HLRQDLERVR NLCYMVSRRE KLSRSLFKLR
EQVFYKQLGV LDEMRLEKQQ TKQEQQQPVM DLNAVIYAND GPTLYDRFYS SVGGQTVPAQ
YQDLKYILEQ LMGKLQSGKQ GRGRASQSPN KRKQPAKASP NKKLNNGILS SRTSSPEKTV
AGSKVGTTTS KVRSPPGKNP TGRRASKSSA AAATSTHNKS QFHSNIRSST TSHSSSGTIS
SGNSSSANGT SSSDSSSGSD SGSESGSSSA GSGVSKRKSS SGSPLKKQSY ARSVEQRQKQ
RQRRQNEAVA GASATYPDSR SASSSSDGED ERCRNRQEPE RGARRGPIQS KSVPNRSQAS
RSKPTTEADV GEGTGASARR KLSTTTRGLA QMDKDADESV SSDESEELLP LRGERQREST
TTSGLATTGS AIGRNLGQHI YSDSESSSSE QEKDQEEQAT VESNVSDSQN QQTIRTKAAM
KEFVPGTAAT TSSTSQAASS TSKAKNTREG KEGAASIGNS TKTKPNPNAK LYPADLLVVP
QRQAAKKASE NMRSTNLATT LQPDVSDRVR EPDINSISGT AKSKVKDSSS RVSNEADKSS
LEKVRPKEHL QKTVGKTSES APAERGKRGR PPKVPKDARP PSITENDKPA LPTHTQSKPP
SVVATPVSAK SNFAVSLVPQ RQAAKKAAEQ LKSSKPVLES FSTGNDISDK ETVTSATISG
SGSSVPAAST PVKPTRRSSI KEAPITPKEP LSGRRKSKED LLATPIKTTP LVKRRVVVPN
LSSSSSGDSE SSSSSSSSGS SSSSGGSDSD SESQASNSEN PSSREPPVAP AKVPSDSSLV
PKRSPRKSMD KPSALTIAPA SVNVLNIPST RSRQNSTTKS TKVALQKAVQ SVEDDVKCTP
KTNRLQGSMD ECGKQVQLEQ ATKRATRGSK SRPPSPTAKS SPEKTVSRCK SRAEESPKKV
ANLEQEISQR KVASGKGTSS LDKLLNKKQQ QMNHSAQATP PPISPTPPAS ETRIVKDQCD
LKPDEVSIQQ INLGADAQPE PDLDPESAAE AGELPMDIDE ELTTAPTRTQ LSASASKLAD
IIDDERPPAA PLPASPTPTP TSNDEMSDAG SDLSERRRMR WRSRRRRRRR SHEPDEEHTH
HTQHLLNEME MARELEEERK NELLANASKY SASTSSPAVT VIPPDPPEII ELDSNSAEQQ
QQHLHDQPLP PPLVVQSPAA DVVPTVMQQQ LLPSQRPLIE QLPVEHLPIV ETILEMEDSK
FANNFASNLA SVLNPPNQMS LIGSSIDRSK QISEEDSIQA TRNLLEKLRK TKRKAQDDCS
SKEAVDLLPP TPAIPSVFPF HNAADPEDII HAQKEQQHQQ QQQLQSSQTC IYGNSSGPNS
VASLTIKDSP MTANSGSYAN SLTNTPNATP TNATMNNLGY QVNFPNSQPP PTLGLFLEKS
PHQKGACPLS SNGGANVGQP APTPDFVDLA AAAVKNTLGS FRGAATVPTQ SGTGVNAKIN
DYDESTRMQS PFGGMPWNES DLIAERRSSS PSSVSESNDP PQPPPVVTAT ATTARSLAQL
ESCKNFFNSY PSGNAGPGTA ANATAPFNHP PMVNGIDSIP MFNNTNTTQH QPTTPAHQQQ
QQRTPNNQYN GTIYPQLAGI MHPQTTPTEP PSSLYGNGGV GGAVQSTTLP PPAQVNQYPG
TPYSATTLGM ISVQQPALST VPVQTATTPN NPFTLTSPID GKMPTYPAQL LSSCAEAVVA
SMMPPTPPVT ATAKDSPSKR TSVSGSNLSK KQTHKSPQLP QGKSPGKSPR QPLQPPTPPA
PVPVVALPPT KYDPQTHTLQ GKPRQRAPRG SGGSGAPGRG RGRGRGRGRG GGVTSGMAMV
LPPPMSDYGS NTHIVNNLVG TPFEFNNEFD DMAGPGVENL QSLRDRRRSF ELRAPRVQNK
PTTTPTTATT TNPLLHPVLP GPVDMRTYNL GFEAPHSTAS QEAYQNNLLG AFDSGTADQT
LSEFNEEDER QFQSALRATG TGTSPSKQHS GPTALVAPPT GPNPTPAPNL LLHCTEANQM
APNVAATGAA THLVEGSLVE ASLEATSEEV SIDSDSTIPH SKTSTSDARS QIKLKIKSPM
AYPEHYNAMT NSSSLTLTST LVQSSNVVQT TVSTSTVVSA SSAVSGNSRR MRKKELLSLY
VVQKDNHNDD SSCGLPAASD TLPLENLRKS EEEDELSGGN GTKRFKKNSS SRELRALDAN
LALVEEQLLS SGAGACGGGS SGDGRRRSAC SSGSNNDNNG KTGAASSAGK RRGRSKTLES
SEDDHQAPKL KIKIRGLTAN ETPSGVSSVD EGQNYSYEMT RRACPPKKRL TSNFSTLTLE
EIKRDSMNYR KKVMQDFVKG EDSNKRGVVV KDGESLIMPQ PPTKRPKSSK PKKEKKEKKR
QKQQQLILSS STTTMTTTLI ENTASASPGD KPKLILRFGK RKAETTTRTA SLEQPPTLEA
PAPLRFKIAR NSSGGGYIIG TKAEKKDEST ADNTSPITEL PLISPLREAS PQGRLLNSFT
PHSQNANTSP ALLGKDTGTP SPPCLVIDSS KSADVHDSTS LPESGEAAMG VQSSLVNATT
PLCVNVGNYE NSNNSLPSAS GTGSASSNSC NSNSINNNGS GGGRASGEGG LLPLKKDCEV
R