RNO_DROPS
ID RNO_DROPS Reviewed; 3313 AA.
AC Q29EQ3;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=PHD finger protein rhinoceros;
GN Name=rno; ORFNames=GA20049;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: May function as a negative regulator of the EGFR/Ras/MAPK
CC signaling pathway during eye development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the JADE family. {ECO:0000305}.
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DR EMBL; CH379070; EAL30007.2; -; Genomic_DNA.
DR SMR; Q29EQ3; -.
DR IntAct; Q29EQ3; 1.
DR STRING; 7237.FBpp0286701; -.
DR PRIDE; Q29EQ3; -.
DR eggNOG; KOG0954; Eukaryota.
DR HOGENOM; CLU_225483_0_0_1; -.
DR InParanoid; Q29EQ3; -.
DR OMA; KYDPQTH; -.
DR ChiTaRS; rno; fly.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042051; P:compound eye photoreceptor development; ISS:UniProtKB.
DR GO; GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF10513; EPL1; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Developmental protein; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..3313
FT /note="PHD finger protein rhinoceros"
FT /id="PRO_0000253538"
FT ZN_FING 323..373
FT /note="PHD-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT ZN_FING 375..409
FT /note="C2HC pre-PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT ZN_FING 433..487
FT /note="PHD-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT REGION 1..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1961..2033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2104..2136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2145..2164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2219..2252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2353..2374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2398..2514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2563..2587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2647..2679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2827..2871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2888..2954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2978..2998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3017..3077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3144..3233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3259..3313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1744..1773
FT /evidence="ECO:0000255"
FT COMPBIAS 100..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..878
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1010
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1074
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1287..1343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1344..1358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1476..1491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1506..1520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1521..1552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1553..1581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1594..1611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1612..1629
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1642..1660
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1733..1767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1795..1842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1962..2033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2104..2135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2404..2436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2437..2457
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2564..2582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2842..2856
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2904..2924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2931..2950
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3048..3064
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3181..3204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3259..3296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3313 AA; 351739 MW; F6BE615AF756D8BB CRC64;
MSQRGKRGNQ HHHQSHHPPP QQQQRKDVEP QPPPTKRRKG RPPNGATTAA AAIAAAAAAA
AAAAAGTATG GDRVPVIPSS NSKNEVEQEL DIGGGGSGLL GAASSSSSIT KSKSTKLAKS
SSKSKSQGAS TSSSWQARSV ADIKMSSIYN RSSTEAPAEL YRKDLISAMK LPDSEPLANY
EYLVVADQWK QEWEKGVQVP VNPDSLPEPC VYVLPEPIVS PAHDFKLPKN RYLRITKDEH
YSPELHCLTN VVALAENTCA YDIDPIDEAW LRLYNSDRAQ CGAFHINETQ FERVIEELEV
RCWEQIQVIL KQEEGLGIEF DENVICDVCR SPDSEEANEM VFCDNCNICV HQACYGITAI
PSGQWLCRTC SMGITPDCVL CPNKAGAMKS NKSGKHWAHV SCALWIPEVS IGCVDRMEPI
TKISSIPQSR WSLVCVLCRK RVGSCIQCSK HSMSKGKKEN AGGASGGGSA SVTSSMHKAN
KYATGTGDGA NEGSSACGKT GEDQRRRKNH RKNDMTSEER NQARAQRLQE VEAEFDKHVN
INDISCHLFD VDDDAIVAIY NYWKLKRKSR HNRELIPPKS EDVEMIARKQ EQQDLENHKL
VVHLRQDLER VRNLCYMVSR REKLSRSLFK LREQVFYKQL GVLDETRLDK QQQKQDDKQR
PALDMDAVIY ANDGPTLYDR FYSSAGGQTV PAQYQNLEYV LEQLMGKLQS GKQGRGRASQ
SPNKRKQVAK ASPTKKLNNG AITSRTSSPE KPAAMGKVPS TSTSTATATT AAKVRGAPPG
KPLAGRRASK SGAATGTSTH NKTQSQSQSH SHIRSSASSH TSSGSSSSGD SSSPNGTSSS
DSSSASDSGS ESGSSSAASG ISRRKSTTGS PLKKQSYARS VEQRQKQRQR RQSEAAAGAS
AASPNSRSAT SSSEDEDEQQ RRRQEPERER DGRGRGAIYN KTVPNRTQPT KSKQSTQADA
GSGAGTGAAV ETGAKRKLST NTRGLAQMHK DAEESLSSDE SEELLPLKNE RQREAALSSG
LAASGPTTGG RKMGQHIYSD SESSSSSNEK EQEEITAVES NVSDSQNQQT IRTKAAMKEF
VPGTAATTTQ SASSATAAAS KFTKSTKEAK EGASSCKANS NAKLPYPADL LVVPQRQAAK
KASENMRSTN LAATLQPDAA DRMREPESHP ATTIAKNKLK DSGSKQATEA DKFGGGDKVR
SKEQSKSTAK SAGEAIVERG KRGRPPKVPR EPPAPSTSST EKEKPPPPAE AKSTAPAAKP
TAAKTSFAVS YVPQRQAAKK AAEQLKSSKP LQDTTFSTAN ESAEKEPAAT TATTTGMTTL
GVATSSPAKP SRRTSLKEAP NTPKESSANR RKSKEEAAAA AKTTTPIKRR IAAPNLSSSS
SGDSDSSSSS SSSGSSSSSG SGSDSDSDSQ ASDAEKPRQA GKEPAPSAAA PCSTVSSNVP
KRSPRKSVDK PAASAAAAAA AAATPAPPPP PQPLTARTRQ NSTNKSPKRV PQKSVATVDI
QDDAQSAPKT HSHRRQSSPD EGSKQVQSEQ VTKRATRGSK SRPPSPVVKS SPEKQTARRK
SRADESPKKI PNLEHEINQR KAASGKATSA LDKMLDKKQQ QINNSTPASP PRKSLTPTPT
PPPARSPLPE KLQREPEPVV EPEVETEIEP ATEAGELPMD IDEELTTAPT HTQLSANASK
LADIIDDERP PAAPLPASPT PTPTSNDELS DAGSDLSERC RSRWRSRRRR RRRSHEPDEE
HTHHTQHLLN EMEMARELEE ERKNELLANA SKYSASTSSP AVTVIPPDPP EIIELDSNSA
NSGGDQQQQQ QQQPLPQQLM VHSPSSEVAS TIQQQQQPPP SHQTLIDQLP VEHMPIVDTI
LEMEDSKFAN NFASSLASVL NPPNPGQMSL LGSSLDRGEQ ISEEDSIQAT RNLLEKLRKT
KRKAQDDCCS KEAVDLLPPT PAIPSVFPFH NAADPEDIIH AQKEQQQQQQ QQQQQQQQQQ
QQQQSCLYGN SSGPNSVASL TIKDSPMTAN SGSYANSLTN TPNATPTNAT MGNNLGASGG
YQVNFGNSQQ APPLSCFLEK SPHQKGGCPL SNNGGAVPGA TPDFVDLAAA AVKNSLGSYQ
AGAPVTAQSG AGSNSNKLSD YDENTRMQSP FGRMQRWNEN DLIAARRSSS PSSVSESNDQ
PPATVAARNI SQLEGCKTFF NSYASGNGGG GSAVNPTAPY SHAPLVNGID GMSMFSNAAA
PQQQTTPTHQ QQQQQQQQQQ QQRTPNSQFN GGIYPQLAVM MHTQSTTTES TPSLYGNGGV
GVVPGVGVGV GAVPTTLPLA PPPQAPQYSG TPYTTPSLGM LPVQQQPVVP PVQVSTTPNH
QFALASPVDG KIPAYPAHPA HPAHPAHPAH PAHPAQLLSS CVEAAVVSMM PPTTPVAVAA
KESPNKRSSA NSGSAAKKQP NKSPQLPQGK SPGKSPRQPV QPQPPTPPAP APAVALPPSK
YDPLTHTIQG KPRQRAPRGS GGSGAPGRGR GRGRGRGRGA GAASGMALPL PPPMSDYGSN
THIVNNLVGT PFEFNNYDDD ITGPGVENLQ SLRDRRRSFE LRTTRGQPKP TPAPTAATTT
NPLLHPVLPG PVDMRTYNLG FEAPHSTASQ EAYQNNLLGA FDSGTADQTL SEFDEEDERQ
FQSALRATGT GTSPSKHPAV SAAPVAPAPA PAANSQPPAN LLLHSTEANQ MAPSVAATGG
ATHLMEGSLV EASLEATSEE VSIDSDTTIM NSKTSICDAR NQLKLKIKSP LAYSGEHYGA
MANSLSSSLS LSSSTLVQSS SAVQTTVSTS TVVSASSVGS GNSRRMRKKE LLSLYVVQKD
NLNDDSSCGL PAASDNLPLG PDFLRKSEEE EDVSTGNGNG SKRFKKNSSS RELRALDANS
VLVEDQQLAG ASGGGAGTAS GDGRRRSACS SGSNNDNNGK TGAATSAGKR RGRSKTLESS
EDDHQTPKLK IKIRGLSGSE AVASAGISNA GDSKSYSYEM TRRACPPKKR LTSNYSTPTL
EEIKRDSMNY RKKVMQDFDK GEENNKQDSS GLPLDGEALM PQPPSKRPKS SKPKKDKKEK
KRQKQKQLIL NSSSATTTMT TTLIENTASA SPGDKPKLIL RINKRKTETS TKITCLEQPP
VNEAPLRLKI ARNLSGGGYI IGAKAEKKED PPPDPPPDPN QPNVSPANEL PLMAPLGETS
PQGLLLNSFT PHSQNANASP ALLGKDSGTP SPPCLVIDSS KSADVHDSTS LPESGVAAMG
VPASLVGATT PLCVNVGNYE NSNNSLPSAS GTGSASSNSC NSNSNNNNNN GSGGGAASGG
GSLLPLKKDC EVR
