RNP1_ARATH
ID RNP1_ARATH Reviewed; 411 AA.
AC Q8W034; O23288;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Heterogeneous nuclear ribonucleoprotein 1;
DE Short=hnRNP1;
GN Name=RNP1; OrderedLocusNames=At4g14300; ORFNames=dl3190w, FCAALL.156;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH TRN1, NUCLEAR LOCALIZATION
RP SIGNAL, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=14756317; DOI=10.1023/b:plan.0000009288.46713.1f;
RA Ziemienowicz A., Haasen D., Staiger D., Merkle T.;
RT "Arabidopsis transportin1 is the nuclear import receptor for the circadian
RT clock-regulated RNA-binding protein AtGRP7.";
RL Plant Mol. Biol. 53:201-212(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP REVIEW, AND GENE FAMILY.
RX PubMed=10740297; DOI=10.1016/s1360-1385(00)01595-8;
RA Lorkovic Z.J., Wieczorek Kirk D.A., Lambermon M.H., Filipowicz W.;
RT "Pre-mRNA splicing in higher plants.";
RL Trends Plant Sci. 5:160-167(2000).
RN [7]
RP GENE FAMILY.
RX PubMed=11809873; DOI=10.1093/nar/30.3.623;
RA Lorkovic Z.J., Barta A.;
RT "Genome analysis: RNA recognition motif (RRM) and K homology (KH) domain
RT RNA-binding proteins from the flowering plant Arabidopsis thaliana.";
RL Nucleic Acids Res. 30:623-635(2002).
CC -!- FUNCTION: Involved with pre-mRNA processing. Forms complexes
CC (ribonucleosomes) with at least 20 other different hnRNP and
CC heterogeneous nuclear RNA in the nucleus (By similarity).
CC {ECO:0000250}.
CC -!- FUNCTION: Involved in the packaging of pre-mRNA into hnRNP particles,
CC transport of poly(A) mRNA from the nucleus to the cytoplasm and may
CC modulate splice site selection. {ECO:0000250}.
CC -!- SUBUNIT: Component of the spliceosome (By similarity). Interacts with
CC TRN1. {ECO:0000250, ECO:0000269|PubMed:14756317}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14756317}. Cytoplasm
CC {ECO:0000269|PubMed:14756317}. Note=Localized in cytoplasmic mRNP
CC granules containing untranslated mRNAs. Shuttles continuously between
CC the nucleus and the cytoplasm along with mRNA. Component of
CC ribonucleosomes. Relocalization from the cytoplasm into the nucleus is
CC mediated by TRN1 (By similarity). {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB10209.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB78472.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ303457; CAC83517.1; -; mRNA.
DR EMBL; Z97335; CAB10209.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161538; CAB78472.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83411.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66890.1; -; Genomic_DNA.
DR EMBL; AK226323; BAE98475.1; -; mRNA.
DR PIR; G71404; G71404.
DR RefSeq; NP_001328758.1; NM_001340917.1.
DR RefSeq; NP_193166.2; NM_117507.5.
DR AlphaFoldDB; Q8W034; -.
DR SMR; Q8W034; -.
DR BioGRID; 12368; 3.
DR IntAct; Q8W034; 2.
DR STRING; 3702.AT4G14300.1; -.
DR iPTMnet; Q8W034; -.
DR PaxDb; Q8W034; -.
DR PRIDE; Q8W034; -.
DR ProteomicsDB; 227952; -.
DR EnsemblPlants; AT4G14300.1; AT4G14300.1; AT4G14300.
DR EnsemblPlants; AT4G14300.2; AT4G14300.2; AT4G14300.
DR GeneID; 827071; -.
DR Gramene; AT4G14300.1; AT4G14300.1; AT4G14300.
DR Gramene; AT4G14300.2; AT4G14300.2; AT4G14300.
DR KEGG; ath:AT4G14300; -.
DR Araport; AT4G14300; -.
DR TAIR; locus:2129590; AT4G14300.
DR eggNOG; KOG4205; Eukaryota.
DR HOGENOM; CLU_012062_1_2_1; -.
DR InParanoid; Q8W034; -.
DR OMA; APRNSWD; -.
DR OrthoDB; 1565323at2759; -.
DR PhylomeDB; Q8W034; -.
DR PRO; PR:Q8W034; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8W034; baseline and differential.
DR Genevisible; Q8W034; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:1901000; P:regulation of response to salt stress; IMP:TAIR.
DR GO; GO:2000070; P:regulation of response to water deprivation; IMP:TAIR.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome;
KW Transport.
FT CHAIN 1..411
FT /note="Heterogeneous nuclear ribonucleoprotein 1"
FT /id="PRO_0000421803"
FT DOMAIN 6..82
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 110..187
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 81..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..390
FT /note="Nuclear targeting sequence (M9)"
FT REGION 358..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 411 AA; 42353 MW; 18143301651FB62F CRC64;
MDSDQGKLFV GGISWETDED KLREHFTNYG EVSQAIVMRD KLTGRPRGFG FVIFSDPSVL
DRVLQEKHSI DTREVDVKRA MSREEQQVSG RTGNLNTSRS SGGDAYNKTK KIFVGGLPPT
LTDEEFRQYF EVYGPVTDVA IMYDQATNRP RGFGFVSFDS EDAVDSVLHK TFHDLSGKQV
EVKRALPKDA NPGGGGRSMG GGGSGGYQGY GGNESSYDGR MDSNRFLQHQ SVGNGLPSYG
SSGYGAGYGN GSNGAGYGAY GGYTGSAGGY GAGATAGYGA TNIPGAGYGS STGVAPRNSW
DTPASSGYGN PGYGSGAAHS GYGVPGAAPP TQSPSGYSNQ GYGYGGYSGS DSGYGNQAAY
GVVGGRPSGG GSNNPGSGGY MGGGYGDGSW RSDPSQGYGG GYNDGQGRQG Q
