RNP24_SCHPO
ID RNP24_SCHPO Reviewed; 369 AA.
AC Q09100; O74303; Q9UU22;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 2.
DT 25-MAY-2022, entry version 139.
DE RecName: Full=RNA-binding protein rnp24;
GN Name=rnp24; ORFNames=SPAC3G6.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8598051; DOI=10.1007/bf02208611;
RA Vanhoy R.W., Wise J.A.;
RT "Molecular analysis of a novel Schizosaccharomyces pombe gene containing
RT two RNP consensus-sequence RNA-binding domains.";
RL Curr. Genet. 29:307-315(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-196, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10759889}.
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DR EMBL; U24430; AAA98604.1; -; Genomic_DNA.
DR EMBL; CU329670; CAB16280.1; -; Genomic_DNA.
DR EMBL; AB027862; BAA87166.1; -; Genomic_DNA.
DR PIR; T38723; T38723.
DR RefSeq; NP_594970.1; NM_001020401.2.
DR AlphaFoldDB; Q09100; -.
DR SMR; Q09100; -.
DR BioGRID; 279405; 13.
DR STRING; 4896.SPAC3G6.04.1; -.
DR iPTMnet; Q09100; -.
DR MaxQB; Q09100; -.
DR PaxDb; Q09100; -.
DR PRIDE; Q09100; -.
DR EnsemblFungi; SPAC3G6.04.1; SPAC3G6.04.1:pep; SPAC3G6.04.
DR GeneID; 2542965; -.
DR KEGG; spo:SPAC3G6.04; -.
DR PomBase; SPAC3G6.04; rnp24.
DR VEuPathDB; FungiDB:SPAC3G6.04; -.
DR eggNOG; KOG4210; Eukaryota.
DR HOGENOM; CLU_027451_0_0_1; -.
DR InParanoid; Q09100; -.
DR OMA; FQHCGEI; -.
DR PhylomeDB; Q09100; -.
DR PRO; PR:Q09100; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; ISO:PomBase.
DR GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR CDD; cd12396; RRM1_Nop13p_fungi; 1.
DR CDD; cd12397; RRM2_Nop13p_fungi; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR034225; Nop13/Rnp24_RRM1.
DR InterPro; IPR034226; Nop13/Rnp24_RRM2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Nucleus; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..369
FT /note="RNA-binding protein rnp24"
FT /id="PRO_0000081808"
FT DOMAIN 105..206
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 228..310
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 343..369
FT /note="RPGAALAKAQRSSAAIVEPAGQKIKFD -> VPVQH (in Ref. 1;
FT AAA98604)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 369 AA; 42074 MW; B595AB826279BC79 CRC64;
MEPIQKMDSL NNKEGQPDKK RKKHESEKEG ENEVLEIDVT KPVPPSKKLM RKLRKAGKID
KDGNWTPEAL EEAKKKEEKR LKRLDAKYGR KEEGESQEES KRSPWGIWVG NLSFHTTKEI
LTDFFVRETS EMIKEVSEEN IKPITTEQIT RIHMPMSKEK RFQNKGFAYV DFATEDALKL
ALQCSEKALN GRNILIKSNT DFSGRPSKPA NTLSKTASIQ SSKKEPSSIL FVGNLDFETT
DADLKEHFGQ VGQIRRVRLM TFEDTGKCKG FGFVDFPDID TCMKAMELGH NSWRLEYGED
RSKRMRNKSP MARSGRFNDA ESLGQEDKPN FKRARKIDPR SVRPGAALAK AQRSSAAIVE
PAGQKIKFD
