ID   RNP3_SCHPO              Reviewed;         235 AA.
AC   P87120;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 2.
DT   25-MAY-2022, entry version 131.
DE   RecName: Full=Probable ribonuclease P protein subunit 3;
DE            EC=3.1.26.5;
GN   ORFNames=SPAC3A12.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Part of ribonuclease P, a protein complex that generates
CC       mature tRNA molecules by cleaving their 5'-ends. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC         from tRNA precursor.; EC=3.1.26.5;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein
CC       component 3 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB08749.2; -; Genomic_DNA.
DR   PIR; T38672; T38672.
DR   RefSeq; NP_593330.1; NM_001018761.1.
DR   AlphaFoldDB; P87120; -.
DR   SMR; P87120; -.
DR   BioGRID; 279496; 2.
DR   STRING; 4896.SPAC3A12.04c.1; -.
DR   MaxQB; P87120; -.
DR   PaxDb; P87120; -.
DR   EnsemblFungi; SPAC3A12.04c.1; SPAC3A12.04c.1:pep; SPAC3A12.04c.
DR   GeneID; 2543062; -.
DR   KEGG; spo:SPAC3A12.04c; -.
DR   PomBase; SPAC3A12.04c; -.
DR   VEuPathDB; FungiDB:SPAC3A12.04c; -.
DR   eggNOG; KOG2363; Eukaryota.
DR   HOGENOM; CLU_048451_3_0_1; -.
DR   InParanoid; P87120; -.
DR   OMA; PWDVINL; -.
DR   PhylomeDB; P87120; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:P87120; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005655; C:nucleolar ribonuclease P complex; ISO:PomBase.
DR   GO; GO:0000172; C:ribonuclease MRP complex; EXP:PomBase.
DR   GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IDA:PomBase.
DR   GO; GO:1905267; P:endonucleolytic cleavage involved in tRNA processing; IDA:PomBase.
DR   GO; GO:0090502; P:RNA phosphodiester bond hydrolysis, endonucleolytic; IBA:GO_Central.
DR   GO; GO:0008033; P:tRNA processing; IBA:GO_Central.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR002738; RNase_P_p30.
DR   PANTHER; PTHR13031; PTHR13031; 1.
DR   Pfam; PF01876; RNase_P_p30; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Nucleus; Reference proteome; tRNA processing.
FT   CHAIN           1..235
FT                   /note="Probable ribonuclease P protein subunit 3"
FT                   /id="PRO_0000140033"
SQ   SEQUENCE   235 AA;  26799 MW;  7A1BD68D1306F99D CRC64;
     MFIDLNVVWP TLGVKDLNLV KTVKTLERLG YTAIALNYQY DGKLQNVIKN PIVKELYPEQ
     KIKIYSRITL TIESMPQNKV LSNVTKEFDI LAIRPIGDRL LQQTCSDLEF DILSIDFTQR
     LPFYLKHTFM GLAVSRDIGI EISYSSGLRD VSNRRNLITN ATSLVRATRG RGIIVTSETR
     TPLECRAGFD VINLATFWDL KQDQARKSVG ESCRSVLLHA ETRRDTYRSI LNGCH