RNP3_THEKO
ID RNP3_THEKO Reviewed; 220 AA.
AC Q5JH47;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Ribonuclease P protein component 3 {ECO:0000255|HAMAP-Rule:MF_00756};
DE Short=RNase P component 3 {ECO:0000255|HAMAP-Rule:MF_00756};
DE EC=3.1.26.5 {ECO:0000255|HAMAP-Rule:MF_00756};
DE AltName: Full=Rpp30 {ECO:0000255|HAMAP-Rule:MF_00756};
GN Name=rnp3 {ECO:0000255|HAMAP-Rule:MF_00756}; OrderedLocusNames=TK1450;
OS Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS (Pyrococcus kodakaraensis (strain KOD1)).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=69014;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX PubMed=15710748; DOI=10.1101/gr.3003105;
RA Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL Genome Res. 15:352-363(2005).
CC -!- FUNCTION: Part of ribonuclease P, a protein complex that generates
CC mature tRNA molecules by cleaving their 5'-ends. {ECO:0000255|HAMAP-
CC Rule:MF_00756}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC from tRNA precursor.; EC=3.1.26.5; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00756};
CC -!- SUBUNIT: Consists of a catalytic RNA component and at least 4-5 protein
CC subunits. {ECO:0000255|HAMAP-Rule:MF_00756}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00756}.
CC -!- SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein
CC component 3 family. {ECO:0000255|HAMAP-Rule:MF_00756}.
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DR EMBL; AP006878; BAD85639.1; -; Genomic_DNA.
DR RefSeq; WP_011250401.1; NC_006624.1.
DR PDB; 3WYZ; X-ray; 2.21 A; A=1-220.
DR PDB; 3WZ0; X-ray; 2.79 A; E/F=1-220.
DR PDBsum; 3WYZ; -.
DR PDBsum; 3WZ0; -.
DR AlphaFoldDB; Q5JH47; -.
DR SMR; Q5JH47; -.
DR STRING; 69014.TK1450; -.
DR EnsemblBacteria; BAD85639; BAD85639; TK1450.
DR GeneID; 3235810; -.
DR KEGG; tko:TK1450; -.
DR PATRIC; fig|69014.16.peg.1412; -.
DR eggNOG; arCOG00307; Archaea.
DR HOGENOM; CLU_1302679_0_0_2; -.
DR InParanoid; Q5JH47; -.
DR OMA; WFDEVVF; -.
DR OrthoDB; 66325at2157; -.
DR PhylomeDB; Q5JH47; -.
DR Proteomes; UP000000536; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030677; C:ribonuclease P complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0001682; P:tRNA 5'-leader removal; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00756; RNase_P_3; 1.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR023539; RNase_P_comp-3_arc.
DR InterPro; IPR002738; RNase_P_p30.
DR Pfam; PF01876; RNase_P_p30; 1.
DR SUPFAM; SSF89550; SSF89550; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Endonuclease; Hydrolase; Nuclease;
KW Reference proteome; tRNA processing.
FT CHAIN 1..220
FT /note="Ribonuclease P protein component 3"
FT /id="PRO_0000140047"
FT STRAND 14..18
FT /evidence="ECO:0007829|PDB:3WYZ"
FT HELIX 21..30
FT /evidence="ECO:0007829|PDB:3WYZ"
FT STRAND 32..41
FT /evidence="ECO:0007829|PDB:3WYZ"
FT HELIX 48..62
FT /evidence="ECO:0007829|PDB:3WYZ"
FT STRAND 63..70
FT /evidence="ECO:0007829|PDB:3WYZ"
FT HELIX 74..83
FT /evidence="ECO:0007829|PDB:3WYZ"
FT STRAND 86..92
FT /evidence="ECO:0007829|PDB:3WYZ"
FT HELIX 96..104
FT /evidence="ECO:0007829|PDB:3WYZ"
FT STRAND 108..111
FT /evidence="ECO:0007829|PDB:3WYZ"
FT TURN 113..116
FT /evidence="ECO:0007829|PDB:3WYZ"
FT STRAND 117..119
FT /evidence="ECO:0007829|PDB:3WYZ"
FT HELIX 124..133
FT /evidence="ECO:0007829|PDB:3WYZ"
FT STRAND 136..141
FT /evidence="ECO:0007829|PDB:3WYZ"
FT HELIX 142..145
FT /evidence="ECO:0007829|PDB:3WYZ"
FT HELIX 149..168
FT /evidence="ECO:0007829|PDB:3WYZ"
FT STRAND 173..176
FT /evidence="ECO:0007829|PDB:3WYZ"
FT STRAND 179..181
FT /evidence="ECO:0007829|PDB:3WYZ"
FT HELIX 182..184
FT /evidence="ECO:0007829|PDB:3WYZ"
FT HELIX 188..198
FT /evidence="ECO:0007829|PDB:3WYZ"
FT HELIX 202..209
FT /evidence="ECO:0007829|PDB:3WYZ"
FT HELIX 211..217
FT /evidence="ECO:0007829|PDB:3WYZ"
SQ SEQUENCE 220 AA; 25270 MW; 02EA82685C7B3EE0 CRC64;
MSEEEVSFSR DYFVEMDVRD EEAHELASDW FDEVVFTKKL VLEDPPDWGS LKEELKELRG
KYGKVALLLV TRKPSLIREV KSRNLKALLY VQGGDMRINR MAIESGVDAL ISPWFGRKDP
GFDHTLAGMA ARRGVAIGFS LSPLLNANPY GRAQILRFMM KTWQLVKKYR VPRFITSSAE
SRWEVRGPRD LMSLGINIGM EIPEARASLN FYPRTIVWKL
