RNP4F_DROME
ID RNP4F_DROME Reviewed; 941 AA.
AC Q9W4D2; A4V3Z4; O18351; O18352; Q2VC69; Q2VC70; Q2VC71; Q2VC72; Q2VC73;
AC Q2XP46;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=RNA-binding protein 4F;
GN Name=Rnp4F {ECO:0000312|EMBL:AAF46022.1};
GN Synonyms=4f-rnp {ECO:0000312|EMBL:CAA75535.1}; ORFNames=CG3312;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAA75533.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A AND B), FUNCTION,
RP SUBCELLULAR LOCATION, AND RNA EDITING.
RC STRAIN=Oregon-R {ECO:0000269|PubMed:9434193};
RC TISSUE=Embryo {ECO:0000269|PubMed:9434193},
RC Head {ECO:0000312|EMBL:CAA75533.1}, and Pupae {ECO:0000269|PubMed:9434193};
RX PubMed=9434193; DOI=10.1016/s0378-1119(97)00465-4;
RA Petschek J.P., Scheckelhoff M.R., Mermer M.J., Vaughn J.C.;
RT "RNA hyperediting and alternative splicing generate mRNA transcript
RT diversity from the Drosophila 4f-rnp locus.";
RL Gene 204:267-276(1997).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF46022.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAF46022.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAL28943.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:12537569};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-243 AND 542-801 (ISOFORMS A AND B), AND
RP ALTERNATIVE SPLICING.
RX PubMed=16497447; DOI=10.1016/j.gene.2005.12.025;
RA Fetherson R.A., Strock S.B., White K.N., Vaughn J.C.;
RT "Alternative pre-mRNA splicing in Drosophila spliceosomal assembly factor
RT RNP-4F during development.";
RL Gene 371:234-245(2006).
RN [6] {ECO:0000305}
RP FUNCTION, RNA EDITING, DEVELOPMENTAL STAGE, AND INTERACTION WITH SAS10.
RC STRAIN=Oregon-R {ECO:0000269|PubMed:12756328};
RX PubMed=12756328; DOI=10.1261/rna.2120703;
RA Peters N.T., Rohrbach J.A., Zalewski B.A., Byrkett C.M., Vaughn J.C.;
RT "RNA editing and regulation of Drosophila 4f-rnp expression by sas-10
RT antisense readthrough mRNA transcripts.";
RL RNA 9:698-710(2003).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; SER-153; SER-713; TYR-717
RP AND SER-718, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: May be involved in gene regulation during development. Binds
CC RNA. {ECO:0000269|PubMed:12756328, ECO:0000269|PubMed:9434193}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:9434193}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A {ECO:0000269|PubMed:9434193}; Synonyms=H6.1, E33.2;
CC IsoId=Q9W4D2-1; Sequence=Displayed;
CC Name=B {ECO:0000269|PubMed:9434193}; Synonyms=Pupal;
CC IsoId=Q9W4D2-2; Sequence=VSP_051659, VSP_051660;
CC -!- DEVELOPMENTAL STAGE: Expressed moderately during embryonic stages (0-18
CC hours) but then declines in late stage embryos (15-21 hours).
CC {ECO:0000269|PubMed:12756328}.
CC -!- RNA EDITING: Modified_positions=9 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 13 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 17 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 21 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 31 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 41 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 46 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 50 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 54 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 57 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 59 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 70 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 80 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 84 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 86 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 91 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 96 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 101 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 107 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 113 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 116 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 130 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 132 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 135 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 138 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 139 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 141 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 163 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 164 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 183 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 190 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 193 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 196 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 200 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 205 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 207 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 213 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 218 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 220 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 225 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 265 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 275 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 298 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 299 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 302 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 311 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 314 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 319 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 321 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 322 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 328 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 354 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 355 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 368 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 381 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 383 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 389 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 393 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 396 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 398 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 400 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 406 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 409 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 430 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 431 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 433 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 437 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 444 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 453 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 456 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 482 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 490 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 492 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 493 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 497 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 510 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 513 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 516 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 520 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 521 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 525 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 540 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 551 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 552 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 553 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 554 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}, 555 {ECO:0000269|PubMed:12756328,
CC ECO:0000269|PubMed:9434193}; Note=Partially edited. RNA editing takes
CC place in adult and creates an intron retention event that leads to a
CC premature stop codon. The RNA edited version is called H8.3. A
CC discistronic transcript of Sas10 and Rnp4F becomes an RNA duplex, which
CC is a target for RNA-editing via Adar editase.;
CC -!- MISCELLANEOUS: [Isoform A]: Intron retention event in non-edited RNA.
CC -!- MISCELLANEOUS: [Isoform B]: Intron excised in non-edited RNA.
CC {ECO:0000305}.
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DR EMBL; Y15249; CAA75533.1; -; mRNA.
DR EMBL; Y15250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Y15251; CAA75535.1; -; mRNA.
DR EMBL; AE014298; AAF46022.1; -; Genomic_DNA.
DR EMBL; AE014298; AAS65263.1; -; Genomic_DNA.
DR EMBL; AY061395; AAL28943.1; -; mRNA.
DR EMBL; DQ269487; ABB89902.1; -; mRNA.
DR EMBL; DQ269488; ABB89903.1; -; mRNA.
DR EMBL; DQ269489; ABB89904.1; -; mRNA.
DR EMBL; DQ269490; ABB89905.1; -; mRNA.
DR EMBL; DQ269491; ABB89906.1; -; mRNA.
DR EMBL; DQ272384; ABB82038.1; -; mRNA.
DR RefSeq; NP_001096883.3; NM_001103413.3. [Q9W4D2-1]
DR RefSeq; NP_001096884.1; NM_001103414.3. [Q9W4D2-1]
DR RefSeq; NP_511047.2; NM_078492.4. [Q9W4D2-1]
DR RefSeq; NP_996353.1; NM_206630.3. [Q9W4D2-1]
DR AlphaFoldDB; Q9W4D2; -.
DR SMR; Q9W4D2; -.
DR BioGRID; 57958; 3.
DR IntAct; Q9W4D2; 1.
DR STRING; 7227.FBpp0089396; -.
DR iPTMnet; Q9W4D2; -.
DR PaxDb; Q9W4D2; -.
DR PeptideAtlas; Q9W4D2; -.
DR PRIDE; Q9W4D2; -.
DR DNASU; 31448; -.
DR EnsemblMetazoa; FBtr0070752; FBpp0070720; FBgn0014024. [Q9W4D2-1]
DR EnsemblMetazoa; FBtr0070753; FBpp0089396; FBgn0014024. [Q9W4D2-1]
DR EnsemblMetazoa; FBtr0112876; FBpp0111789; FBgn0014024. [Q9W4D2-1]
DR EnsemblMetazoa; FBtr0340477; FBpp0309418; FBgn0014024. [Q9W4D2-1]
DR GeneID; 31448; -.
DR KEGG; dme:Dmel_CG3312; -.
DR CTD; 31448; -.
DR FlyBase; FBgn0014024; Rnp4F.
DR VEuPathDB; VectorBase:FBgn0014024; -.
DR eggNOG; KOG0128; Eukaryota.
DR GeneTree; ENSGT00900000141107; -.
DR HOGENOM; CLU_361804_0_0_1; -.
DR InParanoid; Q9W4D2; -.
DR OMA; RYERCYG; -.
DR PhylomeDB; Q9W4D2; -.
DR BioGRID-ORCS; 31448; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 31448; -.
DR PRO; PR:Q9W4D2; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0014024; Expressed in embryonic/larval hemocyte (Drosophila) and 49 other tissues.
DR ExpressionAtlas; Q9W4D2; baseline and differential.
DR Genevisible; Q9W4D2; DM.
DR GO; GO:0061574; C:ASAP complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; ISS:FlyBase.
DR GO; GO:0007417; P:central nervous system development; IMP:FlyBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR008669; LSM_interact.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF05391; Lsm_interact; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00386; HAT; 3.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Developmental protein; Phosphoprotein;
KW Reference proteome; RNA editing; RNA-binding.
FT CHAIN 1..941
FT /note="RNA-binding protein 4F"
FT /id="PRO_0000081811"
FT DOMAIN 724..801
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..32
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 43
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 153
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 713
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 717
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 718
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 625..639
FT /note="YVKPRSRIKPNSQSA -> SLSRASSSNKRIVSH (in isoform B)"
FT /evidence="ECO:0000303|PubMed:16497447,
FT ECO:0000303|PubMed:9434193"
FT /id="VSP_051659"
FT VAR_SEQ 640..941
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:16497447,
FT ECO:0000303|PubMed:9434193"
FT /id="VSP_051660"
FT VARIANT 9
FT /note="R -> G (in RNA edited version)"
FT VARIANT 13
FT /note="K -> R (in RNA edited version)"
FT VARIANT 17
FT /note="E -> G (in RNA edited version)"
FT VARIANT 21
FT /note="E -> G (in RNA edited version)"
FT VARIANT 31
FT /note="Y -> C (in RNA edited version)"
FT VARIANT 41
FT /note="K -> G (in RNA edited version)"
FT VARIANT 46
FT /note="Q -> R (in RNA edited version)"
FT VARIANT 50
FT /note="E -> G (in RNA edited version)"
FT VARIANT 54
FT /note="Q -> R (in RNA edited version)"
FT VARIANT 57
FT /note="E -> G (in RNA edited version)"
FT VARIANT 59
FT /note="K -> R (in RNA edited version)"
FT VARIANT 70
FT /note="T -> A (in RNA edited version)"
FT VARIANT 80
FT /note="M -> V (in RNA edited version)"
FT VARIANT 84
FT /note="E -> G (in RNA edited version)"
FT VARIANT 86
FT /note="I -> V (in RNA edited version)"
FT VARIANT 91
FT /note="E -> G (in RNA edited version)"
FT VARIANT 96
FT /note="E -> G (in RNA edited version)"
FT VARIANT 101
FT /note="N -> G (in RNA edited version)"
FT VARIANT 107
FT /note="R -> G (in RNA edited version)"
FT VARIANT 113
FT /note="S -> G (in RNA edited version)"
FT VARIANT 116
FT /note="S -> G (in RNA edited version)"
FT VARIANT 130
FT /note="N -> S (in RNA edited version)"
FT VARIANT 132
FT /note="E -> G (in RNA edited version)"
FT VARIANT 135
FT /note="S -> G (in RNA edited version)"
FT VARIANT 138
FT /note="D -> G (in RNA edited version)"
FT VARIANT 139
FT /note="S -> G (in RNA edited version)"
FT VARIANT 141
FT /note="S -> G (in RNA edited version)"
FT VARIANT 163
FT /note="K -> R (in RNA edited version)"
FT VARIANT 164
FT /note="K -> G (in RNA edited version)"
FT VARIANT 183
FT /note="K -> G (in RNA edited version)"
FT VARIANT 190
FT /note="E -> G (in RNA edited version)"
FT VARIANT 193
FT /note="N -> G (in RNA edited version)"
FT VARIANT 196
FT /note="T -> A (in RNA edited version)"
FT VARIANT 200
FT /note="H -> R (in RNA edited version)"
FT VARIANT 205
FT /note="Y -> C (in RNA edited version)"
FT VARIANT 207
FT /note="K -> G (in RNA edited version)"
FT VARIANT 213
FT /note="T -> A (in RNA edited version)"
FT VARIANT 218
FT /note="E -> G (in RNA edited version)"
FT VARIANT 220
FT /note="K -> G (in RNA edited version)"
FT VARIANT 225
FT /note="Q -> R (in RNA edited version)"
FT VARIANT 265
FT /note="Y -> C (in RNA edited version)"
FT VARIANT 275
FT /note="K -> R (in RNA edited version)"
FT VARIANT 298
FT /note="K -> G (in RNA edited version)"
FT VARIANT 299
FT /note="H -> R (in RNA edited version)"
FT VARIANT 302
FT /note="T -> A (in RNA edited version)"
FT VARIANT 311
FT /note="Q -> R (in RNA edited version)"
FT VARIANT 314
FT /note="K -> G (in RNA edited version)"
FT VARIANT 319
FT /note="K -> R (in RNA edited version)"
FT VARIANT 321
FT /note="K -> E (in RNA edited version)"
FT VARIANT 322
FT /note="Q -> R (in RNA edited version)"
FT VARIANT 328
FT /note="T -> A (in RNA edited version)"
FT VARIANT 354
FT /note="K -> R (in RNA edited version)"
FT VARIANT 355
FT /note="N -> S (in RNA edited version)"
FT VARIANT 368
FT /note="K -> G (in RNA edited version)"
FT VARIANT 381
FT /note="E -> G (in RNA edited version)"
FT VARIANT 383
FT /note="I -> V (in RNA edited version)"
FT VARIANT 389
FT /note="T -> A (in RNA edited version)"
FT VARIANT 393
FT /note="N -> S (in RNA edited version)"
FT VARIANT 396
FT /note="E -> G (in RNA edited version)"
FT VARIANT 398
FT /note="E -> G (in RNA edited version)"
FT VARIANT 400
FT /note="T -> A (in RNA edited version)"
FT VARIANT 406
FT /note="K -> R (in RNA edited version)"
FT VARIANT 409
FT /note="K -> E (in RNA edited version)"
FT VARIANT 430
FT /note="S -> G (in RNA edited version)"
FT VARIANT 431
FT /note="H -> R (in RNA edited version)"
FT VARIANT 433
FT /note="S -> G (in RNA edited version)"
FT VARIANT 437
FT /note="N -> S (in RNA edited version)"
FT VARIANT 444
FT /note="M -> V (in RNA edited version)"
FT VARIANT 453
FT /note="E -> G (in RNA edited version)"
FT VARIANT 456
FT /note="E -> G (in RNA edited version)"
FT VARIANT 482
FT /note="Y -> C (in RNA edited version)"
FT VARIANT 490
FT /note="S -> G (in RNA edited version)"
FT VARIANT 492
FT /note="E -> G (in RNA edited version)"
FT VARIANT 493
FT /note="Q -> R (in RNA edited version)"
FT VARIANT 497
FT /note="S -> G (in RNA edited version)"
FT VARIANT 510
FT /note="T -> A (in RNA edited version)"
FT VARIANT 513
FT /note="Y -> C (in RNA edited version)"
FT VARIANT 516
FT /note="Q -> R (in RNA edited version)"
FT VARIANT 520
FT /note="R -> G (in RNA edited version)"
FT VARIANT 521
FT /note="Y -> C (in RNA edited version)"
FT VARIANT 525
FT /note="Q -> R (in RNA edited version)"
FT VARIANT 540
FT /note="N -> G (in RNA edited version)"
FT VARIANT 551
FT /note="Y -> E (in RNA edited version)"
FT VARIANT 552
FT /note="P -> R (in RNA edited version)"
FT VARIANT 553
FT /note="G -> F (in RNA edited version)"
FT VARIANT 554
FT /note="S -> E (in RNA edited version)"
FT VARIANT 555
FT /note="S -> I (in RNA edited version)"
FT VARIANT 556..941
FT /note="Missing (in RNA edited version)"
FT CONFLICT 104
FT /note="G -> D (in Ref. 1; CAA75533/CAA75535/Y15250)"
FT /evidence="ECO:0000305"
FT CONFLICT 499
FT /note="R -> G (in Ref. 1; CAA75533/CAA75535/Y15250)"
FT /evidence="ECO:0000305"
FT CONFLICT 672
FT /note="Q -> QQQ (in Ref. 1; CAA75533/CAA75535/Y15250)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 941 AA; 106740 MW; EAF2775B499FECFD CRC64;
MDADKQLERQ LEKELDEMPA EDLDDDAYDE YDLIVIPDQG KGSPQQGHSE SPQQEEEHKS
EELRQRSRPT WPPSSAGGDM TTIELISSDD EPSVEETEGG NAAGRGRARN DSSSSSDDVG
VIEGSELESN SEVSSDSDSD SDNAGGGNQL ERSYQELNAL PSKKFAQMVS LIGIAFKLND
LEKIESSVLE LQNLATVPAH VWLKYLKARL VVTQTDEERK AFEEQCAKAL GYYYSIPLSE
YVVNYLVDQG NVQNHVLWAK LLADYDVERP DFGDKLRSLI STITDENEAA AFVEMLQKHC
VTWTCNVEQR QMIKSVVDKF KQHLDETTRG WDWSEQHKAH VYDVETLSLD DDLKNAVIRF
IFERSVAKFP IVDVLWLSYI EFIQFEGVTV PENEDENEVT AEMVAKRAKR LGKGFLRNTE
LDLANRGVRS HPSVQLNHRF LDLMERSDFE LAEVDEEIRL ILQRIVTDMD MTVELHLDYL
AYRIRNTNAS DEQQVASLRA AFNHAWEELT VLYGDQADTR YEVLQLWAQV EYTQLGSPDN
GREIWRQIMG YPGSSIRGLL WLNFAQMESE YNGGHGTRDV LRKALSQPVL ENGLMVQEFF
RRYERCYGTY ESIAACQALD LPVEYVKPRS RIKPNSQSAY PRQQKLKPRQ QQQQTNREPL
NREQRRRQAH EQQQQQQQQQ KHGIKKSRTE PSGGATSPPS KVKGPANAEA KESNFKYSPN
MEINKIFVRN LHPACSKEEL HELFSPFGTI KDVRLVHKLN KQFKGIAYVE FEKPGEAQRA
VAGRDGCLFK GMNISVAISN PPPRGTSAVK PSVAPKRRVP TSLIPTTLVR QEVAAKKLRL
LLPEPGDISS TSASVDVAIK REANGEEQKG DVQERDEQKG EEQKGEEQKG EEPKGEEQKG
DDQIGEEQSG VEQKGDEKKE EEMPAAVPKS NDDFRKLFLK D
