AB21G_ARATH
ID AB21G_ARATH Reviewed; 672 AA.
AC Q7XA72; Q9LI82;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=ABC transporter G family member 21;
DE Short=ABC transporter ABCG.21;
DE Short=AtABCG21;
DE AltName: Full=White-brown complex homolog protein 21;
DE Short=AtWBC21;
GN Name=ABCG21; Synonyms=WBC21; OrderedLocusNames=At3g25620; ORFNames=T5M7.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7XA72-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7XA72-2; Sequence=VSP_040638, VSP_040639;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
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DR EMBL; AP001313; BAB03081.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77043.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77044.1; -; Genomic_DNA.
DR EMBL; AY064994; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BT010173; AAQ22642.1; -; mRNA.
DR RefSeq; NP_001189973.1; NM_001203044.2. [Q7XA72-1]
DR RefSeq; NP_189190.2; NM_113460.3. [Q7XA72-2]
DR AlphaFoldDB; Q7XA72; -.
DR SMR; Q7XA72; -.
DR BioGRID; 7480; 2.
DR IntAct; Q7XA72; 2.
DR STRING; 3702.AT3G25620.2; -.
DR PaxDb; Q7XA72; -.
DR PRIDE; Q7XA72; -.
DR ProteomicsDB; 245123; -. [Q7XA72-1]
DR EnsemblPlants; AT3G25620.1; AT3G25620.1; AT3G25620. [Q7XA72-2]
DR EnsemblPlants; AT3G25620.2; AT3G25620.2; AT3G25620. [Q7XA72-1]
DR GeneID; 822149; -.
DR Gramene; AT3G25620.1; AT3G25620.1; AT3G25620. [Q7XA72-2]
DR Gramene; AT3G25620.2; AT3G25620.2; AT3G25620. [Q7XA72-1]
DR KEGG; ath:AT3G25620; -.
DR Araport; AT3G25620; -.
DR TAIR; locus:2102350; AT3G25620.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_10_1; -.
DR InParanoid; Q7XA72; -.
DR OMA; DYIIMIT; -.
DR OrthoDB; 1022017at2759; -.
DR PhylomeDB; Q7XA72; -.
DR PRO; PR:Q7XA72; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q7XA72; baseline and differential.
DR Genevisible; Q7XA72; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..672
FT /note="ABC transporter G family member 21"
FT /id="PRO_0000240693"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 543..563
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 576..596
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 649..669
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 68..322
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 411..617
FT /note="ABC transmembrane type-2"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 117..124
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT VAR_SEQ 461..467
FT /note="GLLFFFS -> KQNKPWY (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_040638"
FT VAR_SEQ 468..672
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_040639"
SQ SEQUENCE 672 AA; 75269 MW; 20B2D99215600135 CRC64;
MMPPNEQESS FPKTPSANRH ETSPVQENRF SSPSHVNPCL DDDNDHDGPS HQSRQSSVLR
QSLRPIILKF EELTYSIKSQ TGKGSYWFGS QEPKPNRLVL KCVSGIVKPG ELLAMLGPSG
SGKTTLVTAL AGRLQGKLSG TVSYNGEPFT SSVKRKTGFV TQDDVLYPHL TVMETLTYTA
LLRLPKELTR KEKLEQVEMV VSDLGLTRCC NSVIGGGLIR GISGGERKRV SIGQEMLVNP
SLLLLDEPTS GLDSTTAARI VATLRSLARG GRTVVTTIHQ PSSRLYRMFD KVLVLSEGCP
IYSGDSGRVM EYFGSIGYQP GSSFVNPADF VLDLANGITS DTKQYDQIET NGRLDRLEEQ
NSVKQSLISS YKKNLYPPLK EEVSRTFPQD QTNARLRKKA ITNRWPTSWW MQFSVLLKRG
LKERSHESFS GLRIFMVMSV SLLSGLLWWH SRVAHLQDQV GLLFFFSIFW GFFPLFNAIF
TFPQERPMLI KERSSGIYRL SSYYIARTVG DLPMELILPT IFVTITYWMG GLKPSLTTFI
MTLMIVLYNV LVAQGVGLAL GAILMDAKKA ATLSSVLMLV FLLAGGYYIQ HIPGFIAWLK
YVSFSHYCYK LLVGVQYTWD EVYECGSGLH CSVMDYEGIK NLRIGNMMWD VLALAVMLLL
YRVLAYLALR NL
