1433_DICDI
ID 1433_DICDI Reviewed; 252 AA.
AC P54632; Q1ZXP9;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=14-3-3-like protein;
GN Name=fttB; ORFNames=DDB_G0269138;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9223628; DOI=10.1016/s0167-4889(97)00060-8;
RA Knetsch M.L.W., Van Heusden G.P.H., Ennis H.L., Shaw D.R., Epskamp S.J.P.,
RA Snaar-jagalska B.E.;
RT "Isolation of a dictyostelium discoideum 14-3-3 homologue.";
RL Biochim. Biophys. Acta 1357:243-248(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16512674; DOI=10.1021/pr050350q;
RA Reinders Y., Schulz I., Graef R., Sickmann A.;
RT "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT by comparative proteomic approaches.";
RL J. Proteome Res. 5:589-598(2006).
CC -!- SIMILARITY: Belongs to the 14-3-3 family. {ECO:0000305}.
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DR EMBL; X95568; CAA64814.1; -; mRNA.
DR EMBL; AAFI02000005; EAS66939.1; -; Genomic_DNA.
DR RefSeq; XP_001134475.1; XM_001134475.1.
DR AlphaFoldDB; P54632; -.
DR SMR; P54632; -.
DR STRING; 44689.DDB0232938; -.
DR PaxDb; P54632; -.
DR EnsemblProtists; EAS66939; EAS66939; DDB_G0269138.
DR GeneID; 8617398; -.
DR KEGG; ddi:DDB_G0269138; -.
DR dictyBase; DDB_G0269138; fttB.
DR eggNOG; KOG0841; Eukaryota.
DR HOGENOM; CLU_058290_0_0_1; -.
DR InParanoid; P54632; -.
DR OMA; IPCATTG; -.
DR PhylomeDB; P54632; -.
DR Reactome; R-DDI-165159; MTOR signalling.
DR Reactome; R-DDI-166208; mTORC1-mediated signalling.
DR Reactome; R-DDI-170968; Frs2-mediated activation.
DR Reactome; R-DDI-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-DDI-3371511; HSF1 activation.
DR Reactome; R-DDI-392517; Rap1 signalling.
DR Reactome; R-DDI-430116; GP1b-IX-V activation signalling.
DR Reactome; R-DDI-450385; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
DR Reactome; R-DDI-450513; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.
DR Reactome; R-DDI-5625740; RHO GTPases activate PKNs.
DR Reactome; R-DDI-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-DDI-5673000; RAF activation.
DR Reactome; R-DDI-5674135; MAP2K and MAPK activation.
DR Reactome; R-DDI-5675221; Negative regulation of MAPK pathway.
DR Reactome; R-DDI-6804114; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
DR Reactome; R-DDI-75035; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
DR PRO; PR:P54632; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005938; C:cell cortex; IDA:dictyBase.
DR GO; GO:0005813; C:centrosome; IDA:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0032038; F:myosin II heavy chain binding; IPI:dictyBase.
DR GO; GO:0140582; P:adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway; IMP:dictyBase.
DR GO; GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.
DR GO; GO:0036090; P:cleavage furrow ingression; IMP:dictyBase.
DR GO; GO:0030865; P:cortical cytoskeleton organization; IGI:dictyBase.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IMP:dictyBase.
DR GO; GO:0032467; P:positive regulation of cytokinesis; IGI:dictyBase.
DR GO; GO:0008104; P:protein localization; IMP:dictyBase.
DR GO; GO:0009617; P:response to bacterium; HEP:dictyBase.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR Gene3D; 1.20.190.20; -; 1.
DR InterPro; IPR000308; 14-3-3.
DR InterPro; IPR023409; 14-3-3_CS.
DR InterPro; IPR036815; 14-3-3_dom_sf.
DR InterPro; IPR023410; 14-3-3_domain.
DR PANTHER; PTHR18860; PTHR18860; 1.
DR Pfam; PF00244; 14-3-3; 1.
DR PIRSF; PIRSF000868; 14-3-3; 1.
DR PRINTS; PR00305; 1433ZETA.
DR SMART; SM00101; 14_3_3; 1.
DR SUPFAM; SSF48445; SSF48445; 1.
DR PROSITE; PS00796; 1433_1; 1.
DR PROSITE; PS00797; 1433_2; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..252
FT /note="14-3-3-like protein"
FT /id="PRO_0000058649"
FT CONFLICT 25
FT /note="A -> T (in Ref. 1; CAA64814)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 252 AA; 28704 MW; 30F03CC39D4E273D CRC64;
MTREENVYMA KLAEQAERYE EMVEAMKKVA ELDVELTVEE RNLLSVAYKN VIGARRASWR
IISSIEQKEE SKGNENHVKK IKEYKCKVEK ELTDICNDIL EVLESHLIVS SASGESKVFY
YKMKGDYFRY LAEFATGNPR KTSAESSLIA YKAASDIAVT ELPPTHPIRL GLALNFSVFY
YEILNSPDRA CNLAKTAFDD AIAELDTLSE DSYKDSTLIM QLLRDNLTLW TSDVHNMEKN
QDGDDDQNEP GM
