ID   RNPC3_BOVIN             Reviewed;         516 AA.
AC   Q3MHP0;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=RNA-binding region-containing protein 3;
DE   AltName: Full=RNA-binding motif protein 40;
DE            Short=RNA-binding protein 40;
GN   Name=RNPC3; Synonyms=RBM40;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in pre-mRNA U12-dependent splicing, performed by
CC       the minor spliceosome which removes U12-type introns. U12-type introns
CC       comprises less than 1% of all non-coding sequences. Binds to the 3'-
CC       stem-loop of m(7)G-capped U12 snRNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the U11/U12 snRNPs that are part of the U12-type
CC       spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts
CC       with PDCD7 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC105165; AAI05166.1; -; mRNA.
DR   RefSeq; NP_001070585.1; NM_001077117.2.
DR   AlphaFoldDB; Q3MHP0; -.
DR   SMR; Q3MHP0; -.
DR   STRING; 9913.ENSBTAP00000025416; -.
DR   PaxDb; Q3MHP0; -.
DR   PRIDE; Q3MHP0; -.
DR   GeneID; 768060; -.
DR   KEGG; bta:768060; -.
DR   CTD; 55599; -.
DR   eggNOG; KOG4206; Eukaryota.
DR   InParanoid; Q3MHP0; -.
DR   OrthoDB; 1080666at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0097157; F:pre-mRNA intronic binding; IBA:GO_Central.
DR   GO; GO:0030626; F:U12 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd12238; RRM1_RBM40_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034147; RBM40_RRM1.
DR   InterPro; IPR045164; RBM41/RNPC3.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR16105; PTHR16105; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..516
FT                   /note="RNA-binding region-containing protein 3"
FT                   /id="PRO_0000311111"
FT   DOMAIN          27..102
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          419..502
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..229
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..246
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         21
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96LT9"
FT   MOD_RES         108
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96LT9"
SQ   SEQUENCE   516 AA;  58510 MW;  2274A4484A1794B4 CRC64;
     MAAPEQPLPM SRGCQNSSSL SPPRGDRTLL VRHLPAELTA EEKEDLLKYF GAQSVRDLSD
     KGRLKHTAFA TFPNEKTAVK ALTRLHQLKL LGHTLVVEFA KEQDRVHSPC PSLGTEKKKR
     SDDPVEDDKE KKELDCLTIE NGIAPNHGLT FPLNSCLKYM YPPPSSTILA NIVNALASVP
     KFYVQVLHLM NKMNLPTPFG PITTRPPMYE DYMPLHAPLP PTSPQPPEEP PLPDEDEELS
     SKESEYESSD DEDRQRMTKL MELANLQPKR PKPIKQRHVR KKRKIKDMLN IPSSASHSLH
     PVLLPSDVFD QPQPVGNKKI EFHISTDMQV AFKKDLEKQQ NCEEENSDLP ATEADASNIG
     FGKIFPQPNL NITEEIKDDS DEMPSECISR RELEKGRISR EEMETLSVFR SYEPGEPNCR
     IYVKNLAKHV QEKDLKFIFG RYVDFSSETQ RIMFDIRLMK EGRMKGQAFI GLPNEKAAAK
     ALKEANGYVL FGKPMVVQFA RSARPKQDSK EGKRKC