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RNPC3_MOUSE
ID   RNPC3_MOUSE             Reviewed;         514 AA.
AC   Q3UZ01; Q3TTZ2; Q69Z94; Q80VS9; Q91YJ1; Q9CSC1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=RNA-binding region-containing protein 3;
DE   AltName: Full=RNA-binding motif protein 40;
DE            Short=RNA-binding protein 40;
GN   Name=Rnpc3; Synonyms=Kiaa1839, Rbm40;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Embryo, Skin, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=Czech II, and FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-514 (ISOFORM 1).
RC   TISSUE=Fetal brain;
RX   PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA   Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 11:205-218(2004).
CC   -!- FUNCTION: Participates in pre-mRNA U12-dependent splicing, performed by
CC       the minor spliceosome which removes U12-type introns. U12-type introns
CC       comprises less than 1% of all non-coding sequences. Binds to the 3'-
CC       stem-loop of m(7)G-capped U12 snRNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the U11/U12 snRNPs that are part of the U12-type
CC       spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts
CC       with PDCD7 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3UZ01-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3UZ01-2; Sequence=VSP_029402;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH16603.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK013288; BAB28770.3; -; mRNA.
DR   EMBL; AK134241; BAE22060.1; -; mRNA.
DR   EMBL; AK161063; BAE36180.1; -; mRNA.
DR   EMBL; BC016603; AAH16603.1; ALT_INIT; mRNA.
DR   EMBL; BC043695; AAH43695.1; -; mRNA.
DR   EMBL; AK173272; BAD32550.1; -; mRNA.
DR   CCDS; CCDS17777.1; -. [Q3UZ01-1]
DR   CCDS; CCDS71308.1; -. [Q3UZ01-2]
DR   RefSeq; NP_001033785.1; NM_001038696.1. [Q3UZ01-1]
DR   RefSeq; NP_001273944.1; NM_001287015.1. [Q3UZ01-2]
DR   RefSeq; NP_080319.2; NM_026043.3. [Q3UZ01-1]
DR   AlphaFoldDB; Q3UZ01; -.
DR   SMR; Q3UZ01; -.
DR   BioGRID; 212030; 1.
DR   STRING; 10090.ENSMUSP00000089792; -.
DR   iPTMnet; Q3UZ01; -.
DR   PhosphoSitePlus; Q3UZ01; -.
DR   EPD; Q3UZ01; -.
DR   jPOST; Q3UZ01; -.
DR   MaxQB; Q3UZ01; -.
DR   PaxDb; Q3UZ01; -.
DR   PRIDE; Q3UZ01; -.
DR   ProteomicsDB; 300316; -. [Q3UZ01-1]
DR   ProteomicsDB; 300317; -. [Q3UZ01-2]
DR   Antibodypedia; 9690; 86 antibodies from 23 providers.
DR   Ensembl; ENSMUST00000092154; ENSMUSP00000089792; ENSMUSG00000027981. [Q3UZ01-1]
DR   Ensembl; ENSMUST00000106535; ENSMUSP00000102145; ENSMUSG00000027981. [Q3UZ01-2]
DR   Ensembl; ENSMUST00000106536; ENSMUSP00000102146; ENSMUSG00000027981. [Q3UZ01-1]
DR   GeneID; 67225; -.
DR   KEGG; mmu:67225; -.
DR   UCSC; uc008rbd.1; mouse. [Q3UZ01-1]
DR   UCSC; uc008rbf.1; mouse. [Q3UZ01-2]
DR   CTD; 55599; -.
DR   MGI; MGI:1914475; Rnpc3.
DR   VEuPathDB; HostDB:ENSMUSG00000027981; -.
DR   eggNOG; KOG4206; Eukaryota.
DR   GeneTree; ENSGT00530000063786; -.
DR   InParanoid; Q3UZ01; -.
DR   OMA; RPINTKK; -.
DR   OrthoDB; 1080666at2759; -.
DR   PhylomeDB; Q3UZ01; -.
DR   TreeFam; TF324298; -.
DR   Reactome; R-MMU-72165; mRNA Splicing - Minor Pathway.
DR   BioGRID-ORCS; 67225; 18 hits in 71 CRISPR screens.
DR   ChiTaRS; Rnpc3; mouse.
DR   PRO; PR:Q3UZ01; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q3UZ01; protein.
DR   Bgee; ENSMUSG00000027981; Expressed in retinal neural layer and 269 other tissues.
DR   ExpressionAtlas; Q3UZ01; baseline and differential.
DR   Genevisible; Q3UZ01; MM.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISS:MGI.
DR   GO; GO:0005689; C:U12-type spliceosomal complex; ISS:HGNC.
DR   GO; GO:0097157; F:pre-mRNA intronic binding; IBA:GO_Central.
DR   GO; GO:0030626; F:U12 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd12238; RRM1_RBM40_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034147; RBM40_RRM1.
DR   InterPro; IPR045164; RBM41/RNPC3.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR16105; PTHR16105; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..514
FT                   /note="RNA-binding region-containing protein 3"
FT                   /id="PRO_0000311113"
FT   DOMAIN          27..102
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          418..501
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          213..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          337..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..229
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..246
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         21
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96LT9"
FT   MOD_RES         108
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96LT9"
FT   MOD_RES         349
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4G055"
FT   VAR_SEQ         497
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_029402"
FT   CONFLICT        41
FT                   /note="E -> K (in Ref. 1; BAE22060)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        261
FT                   /note="M -> T (in Ref. 1; BAB28770)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        422
FT                   /note="V -> E (in Ref. 1; BAE22060)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   514 AA;  57972 MW;  0FB772119ED29A0D CRC64;
     MAGPEPPMPL SRGGPGSASL SPPRGDRTLL VRHLPAELTA EEKEDLLKYF GAQSVRVLSD
     KGRLKHTAFA TFPNEKAAIK ALTRLHQLKL LGHTLVVEFA KEQDRVHSPC STSNTEKKKR
     LDDTVENDKE KKEPDILTVE NGIAPNHGLT FPLNSCLKYM YPPPSSTILA NIVNALASVP
     KFYVQVLHLM NKMNLPTPFG PITARPPMYE DYMPLHAPLP PTSPQPPEEP PLPDEDEDLS
     SKESEYESSD EEDRQRMNRL MELANLQPKR PKTEKPRHVR KKRKIKDMLN IPSSASHSLH
     PVLLPSDVFD QPQSVGNKKI EFNISTNMPA AFNKDLETQP NNEEENSDSP DTGLDSNTGF
     GKIFPKPNLN ITEEITEDSD EIPSQFISRK ELEKGRISRE EMETLSVFRS YEPGEPNCRI
     YVKNLARHVQ EKDLKFIFGR YVDFSSETQR IMFDIRLMKE GRMKGQAFVG LPNEKAAAKA
     LKEANGYVLF GKPMVVQFAR SARPKQDSKE GKRK
 
 
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