ID   RNPC3_PONAB             Reviewed;         517 AA.
AC   Q5R6C7;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=RNA-binding region-containing protein 3;
DE   AltName: Full=RNA-binding motif protein 40;
DE            Short=RNA-binding protein 40;
GN   Name=RNPC3; Synonyms=RBM40;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in pre-mRNA U12-dependent splicing, performed by
CC       the minor spliceosome which removes U12-type introns. U12-type introns
CC       comprises less than 1% of all non-coding sequences. Binds to the 3'-
CC       stem-loop of m(7)G-capped U12 snRNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the U11/U12 snRNPs that are part of the U12-type
CC       spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts
CC       with PDCD7 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR860564; CAH92689.1; -; mRNA.
DR   RefSeq; NP_001126576.1; NM_001133104.1.
DR   AlphaFoldDB; Q5R6C7; -.
DR   SMR; Q5R6C7; -.
DR   STRING; 9601.ENSPPYP00000001281; -.
DR   GeneID; 100173567; -.
DR   KEGG; pon:100173567; -.
DR   CTD; 55599; -.
DR   eggNOG; KOG4206; Eukaryota.
DR   InParanoid; Q5R6C7; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd12238; RRM1_RBM40_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034147; RBM40_RRM1.
DR   InterPro; IPR045164; RBM41/RNPC3.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR16105; PTHR16105; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..517
FT                   /note="RNA-binding region-containing protein 3"
FT                   /id="PRO_0000311114"
FT   DOMAIN          27..102
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          420..503
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          213..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..229
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..249
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         21
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96LT9"
FT   MOD_RES         108
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96LT9"
SQ   SEQUENCE   517 AA;  58604 MW;  01B4705D8F17A9D4 CRC64;
     MAAPEQPLAI SRGCTSSSSL SPPRGDRTLL VRHLPAELTA EEKEDLLKYF GAQSVRVLSD
     KGRLKHTAFA TFPNEKAAIK ALTRLHQLKL LGHTLVVEFA KEQDRVHSPC PTSGSEKKKR
     SDDPVEDDKE KKELGYLTVE NGIAPNHGLT FPLNSCLKYM YPPPSSTILA NIVNALASVP
     KFYVQVLHLM NKMNLPTPFG PITARPPMYE DYMPLHAPLP PTSPQPPEEP PLPEEDEELS
     SEESEYESTD DEDRQRMNKL MELANLQPKR PKTIKQRHVR KKRKIKDMLN TPLCPSHSSL
     HPVLLPSDVF DQPQPVGNKR IEFHISTDMP AAFKKDLEKE QNCEEKNHDL PATEVDASNI
     GFGKIFPKPN LDITEEIKED SDEMPSECIS RRELEKGRIS REEMETLSVF RSYEPGEPNC
     RIYVKNLAKH VEEKDLKYIF GRYVDFSSET RRIMFDIRLM KEGRMKGQAF VGLPNEKAAA
     KALKEANGYV LFGKPMVVQF ARSARPKQDP KEGKRKC