ID   RNPS1_XENTR             Reviewed;         309 AA.
AC   Q28E41; Q0VFV0;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=RNA-binding protein with serine-rich domain 1;
GN   Name=rnps1; ORFNames=TEgg030c16.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-309.
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a splicing-dependent multiprotein exon junction
CC       complex (EJC) deposited at splice junction on mRNAs. The EJC is a
CC       dynamic structure consisting of a few core proteins and several more
CC       peripheral nuclear and cytoplasmic associated factors that join the
CC       complex only transiently either during EJC assembly or during
CC       subsequent mRNA metabolism. Putative component of the spliceosome which
CC       enhances the formation of the ATP-dependent A complex of the
CC       spliceosome. May participate in mRNA 3'-end cleavage. Also mediates
CC       increase of mRNA abundance and translational efficiency (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the active spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus speckle
CC       {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Nucleocytoplasmic
CC       shuttling protein. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the splicing factor SR family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-26 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI18692.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR848461; CAJ83719.1; -; mRNA.
DR   EMBL; BC118691; AAI18692.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001015956.1; NM_001015956.3.
DR   AlphaFoldDB; Q28E41; -.
DR   SMR; Q28E41; -.
DR   STRING; 8364.ENSXETP00000052845; -.
DR   PaxDb; Q28E41; -.
DR   GeneID; 548710; -.
DR   KEGG; xtr:548710; -.
DR   CTD; 10921; -.
DR   Xenbase; XB-GENE-941526; rnps1.
DR   eggNOG; KOG4209; Eukaryota.
DR   HOGENOM; CLU_076438_0_0_1; -.
DR   InParanoid; Q28E41; -.
DR   OMA; DPCKNTG; -.
DR   OrthoDB; 1524222at2759; -.
DR   TreeFam; TF314165; -.
DR   Reactome; R-XTR-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-XTR-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-XTR-72187; mRNA 3'-end processing.
DR   Reactome; R-XTR-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0061574; C:ASAP complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd12365; RRM_RNPS1; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034201; RNPS1_RRM.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..309
FT                   /note="RNA-binding protein with serine-rich domain 1"
FT                   /id="PRO_0000378577"
FT   DOMAIN          164..243
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          249..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..69
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..129
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..309
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   309 AA;  34794 MW;  51FCB9B3E18E3BE4 CRC64;
     MAATRHNERD GLSDLRRDRQ RKSGKMAPSP SKRKERSEDR AKDRGKEKAP GKEGTDKDRG
     RDKARKRRSA SSGSSSSSRS RSSSSSSSSS GSSSGSSSGS SSSSASSRSG SSSSSRSSSS
     SSSSGSPSPS RRRHDNRRRS RSKSKQPKRD EKERKRRSPS PRPTKVHIGR LTRNVTKDHI
     LEIFSTYGKI KMIDMPVDRY HPHLSKGYAY VEFEAPEEAE KALKHMDGGQ IDGQEITASA
     VLTPWPMRAM PRRFSPPRRM LPPPPMWRRS PPRMRRRSRS PRRRSPVRRR SRSPARRRHR
     SRSSSNSSR