ID   RNR_CHLMU               Reviewed;         692 AA.
AC   Q9PK00;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Ribonuclease R {ECO:0000255|HAMAP-Rule:MF_01895};
DE            Short=RNase R {ECO:0000255|HAMAP-Rule:MF_01895};
DE            EC=3.1.13.1 {ECO:0000255|HAMAP-Rule:MF_01895};
DE   AltName: Full=VacB protein homolog;
GN   Name=rnr {ECO:0000255|HAMAP-Rule:MF_01895}; Synonyms=vacB;
GN   OrderedLocusNames=TC_0676;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC       monophosphates and is involved in maturation of structured RNAs.
CC       {ECO:0000255|HAMAP-Rule:MF_01895}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC         nucleoside 5'-phosphates.; EC=3.1.13.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01895};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01895}.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01895}.
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DR   EMBL; AE002160; AAF73588.1; -; Genomic_DNA.
DR   RefSeq; WP_010231197.1; NZ_CP027217.1.
DR   AlphaFoldDB; Q9PK00; -.
DR   SMR; Q9PK00; -.
DR   STRING; 243161.TC_0676; -.
DR   EnsemblBacteria; AAF73588; AAF73588; TC_0676.
DR   GeneID; 1246037; -.
DR   KEGG; cmu:TC_0676; -.
DR   eggNOG; COG0557; Bacteria.
DR   HOGENOM; CLU_002333_7_3_0; -.
DR   OMA; DWYEYRS; -.
DR   OrthoDB; 1602988at2; -.
DR   Proteomes; UP000000800; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_01895; RNase_R; 1.
DR   InterPro; IPR011129; CSD.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR013223; RNase_B_OB_dom.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR004476; RNase_II/RNase_R.
DR   InterPro; IPR011805; RNase_R.
DR   Pfam; PF08206; OB_RNB; 1.
DR   Pfam; PF00773; RNB; 1.
DR   SMART; SM00357; CSP; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; SSF50249; 2.
DR   TIGRFAMs; TIGR00358; 3_prime_RNase; 1.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; RNA-binding.
FT   CHAIN           1..692
FT                   /note="Ribonuclease R"
FT                   /id="PRO_0000166399"
FT   DOMAIN          563..648
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01895"
FT   REGION          651..692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        657..692
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   692 AA;  77600 MW;  687DFA3E993A5AAE CRC64;
     MGKAKNKKKV LKNKQQVLVP GILFVHPKKG FGFVSPDQPD LYPFDIFVPA SDLKGALDGD
     HVLVALPFSQ RGGEKRKGVI HKVLSRGKTV LVGTIISLIS PTLAMVCVNA ISPEVPLKAE
     LLPKRTYKIG DRLLLKTPGW KENYPSKEPP PLAMLEFMGN ISNAKTDFPV IKAEFSITEE
     FPEAVVQEAS QFLQKHVTQA LHSRKDLRDL LCFTIDSASA KDFDDAVSLT YDHEGNYILG
     VHIADVSHYV TPNSALDQEA AKRCNSIYFP GKVIPMLPSA LSDNLCSLKP NVDRLAVSVF
     MTFSKEGFLS DYRILRSVIR SKYRMTYDEV DEIIEKKLAH PISKTILEMA ELSRIFSDIR
     EQRGCTRLVL PSFTMSLDNL QEPVALVENK QTAAHKLIEE FMLKANEVIA YHISHQGITM
     PFRIHEPPNE ENLLLFRETA KAMGFTITQT PTQEPDYQYL LQETSAGHPL EPILHSQFVR
     SMKTASYSTE NKGHYGLCLD YYTHFTSPIR RYVDLIVHRL LFHPLSVEEG HLEQIVRACS
     SQERVAAKAE GAFINIKKAR FLKKFLDEQP ATLYKAFIIT VSPEGLSFVL PELCHEGFIP
     AAKLPKKYVI KTKLGLEELP EHLLPGIPIS VQLASVTLLT QAIEWTLIES KERSSSKKKK
     AKAKSNATQV KKKSSSKKKK AVSKAKKNRG GK