RNR_CHLPN
ID RNR_CHLPN Reviewed; 676 AA.
AC Q9Z848; Q9JQ39;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=Ribonuclease R {ECO:0000255|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000255|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000255|HAMAP-Rule:MF_01895};
DE AltName: Full=VacB protein homolog;
GN Name=rnr {ECO:0000255|HAMAP-Rule:MF_01895}; Synonyms=vacB;
GN OrderedLocusNames=CPn_0504, CP_0249, CpB0525;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000255|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01895}.
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DR EMBL; AE001363; AAD18644.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF73648.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98710.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98454.1; -; Genomic_DNA.
DR PIR; B72071; B72071.
DR PIR; D86553; D86553.
DR RefSeq; NP_224700.1; NC_000922.1.
DR RefSeq; WP_010883142.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z848; -.
DR SMR; Q9Z848; -.
DR STRING; 115711.CP_0249; -.
DR EnsemblBacteria; AAD18644; AAD18644; CPn_0504.
DR EnsemblBacteria; AAF73648; AAF73648; CP_0249.
DR GeneID; 45050547; -.
DR KEGG; cpa:CP_0249; -.
DR KEGG; cpj:vacB; -.
DR KEGG; cpn:CPn_0504; -.
DR KEGG; cpt:CpB0525; -.
DR PATRIC; fig|115713.3.peg.563; -.
DR eggNOG; COG0557; Bacteria.
DR HOGENOM; CLU_002333_7_3_0; -.
DR OrthoDB; 1602988at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR013223; RNase_B_OB_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR Pfam; PF08206; OB_RNB; 1.
DR Pfam; PF00773; RNB; 1.
DR SMART; SM00357; CSP; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; SSF50249; 2.
DR TIGRFAMs; TIGR00358; 3_prime_RNase; 1.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; RNA-binding.
FT CHAIN 1..676
FT /note="Ribonuclease R"
FT /id="PRO_0000166400"
FT DOMAIN 566..651
FT /note="S1 motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01895"
FT REGION 656..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..676
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 76354 MW; C2474E942288FABC CRC64;
MLKKPKRKPG RRTYGKSLKI FIPGTLFVHA RKGFGFVSPD NPEEYPFDIF VPARDLRGAL
DGDHVIVSVL PYPRDGQKLK GTISEVLARG KTTLVGTITS LVSPTSALAY TSMSGSQSLI
PVELLPGRTY KIGDRILLST PPWVDKPQEG ASPALQMLEF IGHITNAKAD FQAIQAEYNL
AEEFPPEVIE EASLFSQKHI TQVLHSRKDL RDLLCFTIDS STARDFDDAI SLTYDHNNNY
ILGVHIADVS HYVTPHSHLD KEAAKRCNST YFPGKVIPML PSALSDNLCS LKPNVDRLAV
SVFMTFTKSG HLSDYQIFRS VIRSKYRMTY DEVDNIIEKK HSHPLSKILN EMATLSKKFS
DIREERGCIR FVLPSVTMSL DNLQEPVALI ENHQTFSHKL IEEFMLKANE VVAYHISHQG
VSLPFRSHEP PNDENLLAFQ ELAKNMGFDI TFTPTQEPDY QYLLQTTSAG HPLEQVLHSQ
FVRSMKTASY STENKGHYGL KLDYYTHFTS PIRRYIDLIV HRLLFNPLSI DQTHLEIIVR
ACSTKERVSA KAENSFENLK KTRFINKFLQ EQPKTTYHAY IITANHEGLS FVVTEFCHEG
FIAAAELPKE YSLKKNALPE SIPDKMKPGA SIKVTIDSVN LLTQKIVWSI ATTTEDKPKK
IKKTPSKKKG TKKRAS
