RNR_MYCGE
ID RNR_MYCGE Reviewed; 725 AA.
AC P47350;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Ribonuclease R {ECO:0000255|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000255|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000255|HAMAP-Rule:MF_01895};
DE AltName: Full=VacB protein homolog;
GN Name=rnr {ECO:0000255|HAMAP-Rule:MF_01895}; Synonyms=vacB;
GN OrderedLocusNames=MG104;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-163.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL J. Bacteriol. 175:7918-7930(1993).
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000255|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01895}.
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DR EMBL; L43967; AAC71322.1; -; Genomic_DNA.
DR EMBL; U01795; AAD12320.1; -; Genomic_DNA.
DR PIR; E64211; E64211.
DR RefSeq; WP_009885662.1; NZ_AAGX01000002.1.
DR AlphaFoldDB; P47350; -.
DR SMR; P47350; -.
DR STRING; 243273.MG_104; -.
DR PRIDE; P47350; -.
DR EnsemblBacteria; AAC71322; AAC71322; MG_104.
DR KEGG; mge:MG_104; -.
DR eggNOG; COG0557; Bacteria.
DR HOGENOM; CLU_002333_7_3_14; -.
DR OMA; DWYEYRS; -.
DR OrthoDB; 1602988at2; -.
DR BioCyc; MGEN243273:G1GJ2-117-MON; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR022967; S1_dom.
DR InterPro; IPR003029; S1_domain.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00357; CSP; 1.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; SSF50249; 3.
DR TIGRFAMs; TIGR00358; 3_prime_RNase; 1.
DR TIGRFAMs; TIGR02063; RNase_R; 1.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome;
KW RNA-binding.
FT CHAIN 1..725
FT /note="Ribonuclease R"
FT /id="PRO_0000166408"
FT DOMAIN 644..725
FT /note="S1 motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01895"
SQ SEQUENCE 725 AA; 82899 MW; CC145605C4ADCCBB CRC64;
MKVLTELQKQ IFTIVKKENG KPIPPGIVVR MMENSPNFPG KHLIYRAIDD LLDWAILRKA
GGVTNQLLVN YEPAEPLLDK KLQGILTLGN KNSGFIRSLD DDKTVYYVHY SNLTGALDGD
LVEFCKLDKP QFGDKFDAAV ITILKRARIL YAGNFLVDQN EFALEYKIVA DNPRFYLTMI
VNPDSIPNNL ASNTKIAFQI DEYDPDNNLC KVSVQQVLGN NDDPLINIKA IMLDNSIVFE
TNDVVEQHAN KLSFDTEEQH KAYRQDLTDL AFVTVDPTTS KDLDDAIYVK TIPTGFVLYV
AIADVAHYVN RNSEIDIEAK HKTSSIYLPG HYVVPMLPEQ LSNQLCSLNP AQKRYVVVCE
ISFDNQGRIK TNKLYPATII SKNRFSYDQV NKWLNNKSEL NCDETVINSL KAAFTLSDLI
QAQRQKRGTI DLSHKETEIV VDEHYFPIKI NFLVHDKAET MIENLMVVAN ETVAWVLTNN
KIALPYRVHP RPSKKKLQSL IETVGELNIT KPQFNLDTVT SSQIASWLNE NKDNPSYEIF
VILLLRTLGK AFYSVNPLMH FSIGSNHYTH FTSPIRRYID LTIHRLLWMH LFTPDQFTDN
ERDQLKQELE KIADTVNDTE IKIINCERNA NDYLTTLLLS KQIGKTFSGF ISAITSFGIF
MRMDENNFDG LIKITTIPDD FFIFEKEKMV LKGRKTNKVY KIGDRLEAKL SEIDFIQKRA
ILTLI
