ID   RNR_MYCPU               Reviewed;         725 AA.
AC   Q98QL0;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Ribonuclease R {ECO:0000255|HAMAP-Rule:MF_01895};
DE            Short=RNase R {ECO:0000255|HAMAP-Rule:MF_01895};
DE            EC=3.1.13.1 {ECO:0000255|HAMAP-Rule:MF_01895};
DE   AltName: Full=VacB protein homolog;
GN   Name=rnr {ECO:0000255|HAMAP-Rule:MF_01895}; Synonyms=vacB;
GN   OrderedLocusNames=MYPU_3510;
OS   Mycoplasmopsis pulmonis (strain UAB CTIP) (Mycoplasma pulmonis).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasmopsis.
OX   NCBI_TaxID=272635;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAB CTIP;
RX   PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA   Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA   Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.;
RT   "The complete genome sequence of the murine respiratory pathogen Mycoplasma
RT   pulmonis.";
RL   Nucleic Acids Res. 29:2145-2153(2001).
CC   -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC       monophosphates and is involved in maturation of structured RNAs.
CC       {ECO:0000255|HAMAP-Rule:MF_01895}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC         nucleoside 5'-phosphates.; EC=3.1.13.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01895};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01895}.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01895}.
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DR   EMBL; AL445564; CAC13524.1; -; Genomic_DNA.
DR   PIR; G90555; G90555.
DR   RefSeq; WP_010925155.1; NC_002771.1.
DR   AlphaFoldDB; Q98QL0; -.
DR   SMR; Q98QL0; -.
DR   STRING; 272635.MYPU_3510; -.
DR   EnsemblBacteria; CAC13524; CAC13524; CAC13524.
DR   KEGG; mpu:MYPU_3510; -.
DR   eggNOG; COG0557; Bacteria.
DR   HOGENOM; CLU_002333_7_3_14; -.
DR   OMA; DWYEYRS; -.
DR   OrthoDB; 1602988at2; -.
DR   BioCyc; MPUL272635:G1GT6-351-MON; -.
DR   Proteomes; UP000000528; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.50.140; -; 2.
DR   HAMAP; MF_01895; RNase_R; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR004476; RNase_II/RNase_R.
DR   InterPro; IPR011805; RNase_R.
DR   InterPro; IPR022967; S1_dom.
DR   InterPro; IPR003029; S1_domain.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00955; RNB; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; SSF50249; 3.
DR   TIGRFAMs; TIGR00358; 3_prime_RNase; 1.
DR   TIGRFAMs; TIGR02063; RNase_R; 1.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..725
FT                   /note="Ribonuclease R"
FT                   /id="PRO_0000166410"
FT   DOMAIN          611..689
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01895"
SQ   SEQUENCE   725 AA;  83720 MW;  FF734E9E7D27A5CD CRC64;
     MKNLVLQNLK SNKAYSFLEI ARINKINPNF NSQLSKALFS LLDQGLIVKN NDGNFIKVNE
     IKKIQGIFKQ SNRNFAFIET ADEQSYFVAK AHFNGAINSF EVEAIVYESP FEKDKKYAVV
     KKILKNTHPE IIGFIKISNG IKYFNAFEES FRSYKFFVDQ NIDVEEDDVI LVVVEKIVDQ
     KIYVNFVKKV STLKSNFYQI DIVLEKSKTI IDFPEDVLDE SALIEDHVIE KDYQNRKDLR
     DKLIITIDGE DTKDFDDAIY VEKNKDHFLL SVHIADVAHY VKENSAIDKE ALRRATSIYL
     PHMVIPMLPE KLSNGICSLN PGVDRLVMSI DIFIDFQGNT IKTELYEGII NSKHRLTYNQ
     VNDFYNNKIK LDPNLEKMLN DSLELSKILE NYKKDEGYIN LEIEESKVIL DKEGKTVGIK
     VIQRGLSEVL IENFMVRANE AVAWKMNKLK LPSIYRVHDN PSIESLVLFE KTLKTLGIDF
     DTPKITSPKA FSDSFEKIKQ NYQIDNFVKL MVLRTMEKAI YSDKNIGHFG LASSYYSHFT
     SPIRRYPDLQ LHRLIKQMVF DKSNLKEKKN HFSLILSDVS VQSSKKEVEA VSIERQINDI
     KKAEYYESKI GKSLKAQIVS ILSFGMFVEF EDKVSGLIHI SNLLGEDFQV SEDGLLISSN
     KTKYKLGQEI DVVVVKVDKN LGKVDVVLEK DYQEYLKKEQ AFQAFKKNKF TQDKEKQNGK
     INYKK