ID   RNR_UREPA               Reviewed;         721 AA.
AC   Q9PR88;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Ribonuclease R {ECO:0000255|HAMAP-Rule:MF_01895};
DE            Short=RNase R {ECO:0000255|HAMAP-Rule:MF_01895};
DE            EC=3.1.13.1 {ECO:0000255|HAMAP-Rule:MF_01895};
DE   AltName: Full=VacB protein homolog;
GN   Name=rnr {ECO:0000255|HAMAP-Rule:MF_01895}; Synonyms=vacB;
GN   OrderedLocusNames=UU057;
OS   Ureaplasma parvum serovar 3 (strain ATCC 700970).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=273119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700970;
RX   PubMed=11048724; DOI=10.1038/35037619;
RA   Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA   Cassell G.H.;
RT   "The complete sequence of the mucosal pathogen Ureaplasma urealyticum.";
RL   Nature 407:757-762(2000).
CC   -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC       monophosphates and is involved in maturation of structured RNAs.
CC       {ECO:0000255|HAMAP-Rule:MF_01895}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC         nucleoside 5'-phosphates.; EC=3.1.13.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01895};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01895}.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01895}.
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DR   EMBL; AF222894; AAF30462.1; -; Genomic_DNA.
DR   RefSeq; WP_006688547.1; NC_002162.1.
DR   AlphaFoldDB; Q9PR88; -.
DR   SMR; Q9PR88; -.
DR   STRING; 273119.UU057; -.
DR   EnsemblBacteria; AAF30462; AAF30462; UU057.
DR   GeneID; 29672268; -.
DR   KEGG; uur:UU057; -.
DR   eggNOG; COG0557; Bacteria.
DR   HOGENOM; CLU_002333_7_3_14; -.
DR   OMA; DWYEYRS; -.
DR   Proteomes; UP000000423; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.50.140; -; 2.
DR   HAMAP; MF_01895; RNase_R; 1.
DR   InterPro; IPR040476; CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR004476; RNase_II/RNase_R.
DR   InterPro; IPR011805; RNase_R.
DR   InterPro; IPR022967; S1_dom.
DR   InterPro; IPR003029; S1_domain.
DR   Pfam; PF17876; CSD2; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00955; RNB; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; SSF50249; 2.
DR   TIGRFAMs; TIGR00358; 3_prime_RNase; 1.
DR   TIGRFAMs; TIGR02063; RNase_R; 1.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..721
FT                   /note="Ribonuclease R"
FT                   /id="PRO_0000166414"
FT   DOMAIN          639..719
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01895"
SQ   SEQUENCE   721 AA;  83174 MW;  67EEFA9A4E4FD4AA CRC64;
     MSDFTKQTIT EVISKEERPI PAAILAKKVL EKIPTLNKTD VYKLIDLLIQ ENTIKKLENN
     RLVIGYLDYE FDHEIKQGII TINSKGDGFI KEDNTEIEYY VNKKYLNGAL KKDSVKFVKL
     KKEPKNNLQD AAVIEIVGHA KDHYVGQFIT LPNGGYYIFV DDPLFYLNIN LKDTTGLVNG
     HKILFKIISQ TTKDAIAELV HIIGHKNDVG SDVLSIVYDN GIDPTFDPQV VDLASKLEFY
     VDEHQNKIRR SIIDREIISI DPVGSKDIDD AVYVKKLNDQ RYFLGISIAD VSFYVQPNTI
     LDADAFKRGT STYLVDRVIP MLPHNISNNI CSLNEGEFRM CITCDMVIDK DGKICWKDVY
     PAIMKNYRQM SYDEVNDFYE GKSRFESATL TMKEMLLEAK ELHHILRNKK IKDGYVDFDI
     KEPKIILDET GVPIDIKIYE RKTAQMMVED FMIAANEAVT MFAEEHMDKT LKEFNLEMPF
     IYRVHDKPSI INLQKFEIEA KKLSFNISHD FENIQPNTIS NWLKMNDNHV NLPLISKLLL
     RSMAKASYEI INTGHFGLAS DNYTHFTSPI RRYPDLIVHR LLWMFIFDSQ SYTDKQRVEL
     VNKLKLITEE SNKNEIIAVK TERDVNAAKF AEYMNLHIGK EFIGVVTTVS SFGVFVELEN
     TIEGLIRIKN LKDDFYDFIP ENMTLVGQKR KKIITVGNKV RVRVIEANKL TRKIDFELVA
     Q