ID   RNS10_BOVIN             Reviewed;         211 AA.
AC   Q70IB2; F1MSQ3;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-JAN-2014, sequence version 2.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Inactive ribonuclease-like protein 10;
DE   AltName: Full=Protein Train A;
DE   Flags: Precursor;
GN   Name=RNASE10;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-162.
RC   TISSUE=Epididymis;
RX   PubMed=14561640; DOI=10.1095/biolreprod.103.022459;
RA   Castella S., Fouchecourt S., Teixeira-Gomes A.P., Vinh J., Belghazi M.,
RA   Dacheux F., Dacheux J.-L.;
RT   "Identification of a member of a new RNase A family specifically secreted
RT   by epididymal caput epithelium.";
RL   Biol. Reprod. 70:319-328(2004).
CC   -!- FUNCTION: Secreted proximal epididymal protein required for post-
CC       testicular sperm maturation and male fertility. May be involved in
CC       sperm adhesion to the egg zona pellucida. Does not have ribonuclease
CC       activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: The N-terminus is blocked. Glycosylated (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000305}.
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DR   EMBL; DAAA02028331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJ580633; CAE45265.1; -; mRNA.
DR   RefSeq; XP_001790572.1; XM_001790520.4.
DR   RefSeq; XP_002690790.1; XM_002690744.4.
DR   RefSeq; XP_005193663.1; XM_005193606.3.
DR   RefSeq; XP_005211592.1; XM_005211535.3.
DR   AlphaFoldDB; Q70IB2; -.
DR   SMR; Q70IB2; -.
DR   STRING; 9913.ENSBTAP00000043940; -.
DR   PaxDb; Q70IB2; -.
DR   PRIDE; Q70IB2; -.
DR   Ensembl; ENSBTAT00000046664; ENSBTAP00000043940; ENSBTAG00000032869.
DR   GeneID; 100140137; -.
DR   KEGG; bta:100140137; -.
DR   CTD; 338879; -.
DR   VEuPathDB; HostDB:ENSBTAG00000032869; -.
DR   eggNOG; ENOG502RPGF; Eukaryota.
DR   GeneTree; ENSGT00730000111443; -.
DR   HOGENOM; CLU_1280301_0_0_1; -.
DR   InParanoid; Q70IB2; -.
DR   OMA; GQVTPHC; -.
DR   OrthoDB; 1349885at2759; -.
DR   TreeFam; TF337410; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000032869; Expressed in caput epididymis and 94 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0034113; P:heterotypic cell-cell adhesion; ISS:UniProtKB.
DR   GO; GO:0022409; P:positive regulation of cell-cell adhesion; ISS:UniProtKB.
DR   GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.130.10; -; 1.
DR   InterPro; IPR029742; RNASE10.
DR   InterPro; IPR001427; RNaseA.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
DR   InterPro; IPR023412; RNaseA_domain.
DR   PANTHER; PTHR11437; PTHR11437; 1.
DR   PANTHER; PTHR11437:SF2; PTHR11437:SF2; 1.
DR   Pfam; PF00074; RnaseA; 1.
DR   PRINTS; PR00794; RIBONUCLEASE.
DR   SMART; SM00092; RNAse_Pc; 1.
DR   SUPFAM; SSF54076; SSF54076; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Fertilization; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..211
FT                   /note="Inactive ribonuclease-like protein 10"
FT                   /id="PRO_0000045961"
FT   CONFLICT        8
FT                   /note="I -> F (in Ref. 2; CAE45265)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        25
FT                   /note="V -> L (in Ref. 2; CAE45265)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   211 AA;  23363 MW;  E590232278E62CDB CRC64;
     MKLTLVQIFF MMLLLLLGLG VGLGVGLQMA AAVLEESDQL LDEFLSSDSQ DKAEATKEGL
     ASRSTETLLV SNKEVVQPED TIISEDEVGG DRMLRAEVLL HSNKDYLRSD VMDRECNALM
     ALKVKSKDHT CIPQYIFIHE ELDAVKAVCK SPAVACDLKG GKCHKSPRPF DLTFCKLSKS
     GQVIPHCNYV TFILEKYILM SCSDMKVQIT S