RNS10_HUMAN
ID RNS10_HUMAN Reviewed; 216 AA.
AC Q5GAN6; A2RUQ3; B4DKY4;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Inactive ribonuclease-like protein 10;
DE Flags: Precursor;
GN Name=RNASE10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=15676279; DOI=10.1016/j.ygeno.2004.10.008;
RA Cho S., Beintema J.J., Zhang J.;
RT "The ribonuclease A superfamily of mammals and birds: identifying new
RT members and tracing evolutionary histories.";
RL Genomics 85:208-220(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Secreted proximal epididymal protein required for post-
CC testicular sperm maturation and male fertility. May be involved in
CC sperm adhesion to the egg zona pellucida. Does not have ribonuclease
CC activity (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q5GAN6; Q13515: BFSP2; NbExp=3; IntAct=EBI-12423312, EBI-10229433;
CC Q5GAN6; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-12423312, EBI-6942903;
CC Q5GAN6; Q6IN84: MRM1; NbExp=3; IntAct=EBI-12423312, EBI-5454865;
CC Q5GAN6; O95470: SGPL1; NbExp=3; IntAct=EBI-12423312, EBI-1046170;
CC Q5GAN6; O43765: SGTA; NbExp=5; IntAct=EBI-12423312, EBI-347996;
CC Q5GAN6; Q96EQ0: SGTB; NbExp=3; IntAct=EBI-12423312, EBI-744081;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5GAN6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5GAN6-2; Sequence=VSP_053579;
CC -!- PTM: The N-terminus is blocked. Glycosylated (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC {ECO:0000305}.
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DR EMBL; AY665805; AAV87183.1; -; mRNA.
DR EMBL; AK296766; BAG59346.1; -; mRNA.
DR EMBL; AL355075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471078; EAW66457.1; -; Genomic_DNA.
DR EMBL; BC133002; AAI33003.1; -; mRNA.
DR EMBL; BC133028; AAI33029.1; -; mRNA.
DR CCDS; CCDS32035.1; -. [Q5GAN6-1]
DR RefSeq; NP_001012993.1; NM_001012975.1. [Q5GAN6-1]
DR AlphaFoldDB; Q5GAN6; -.
DR SMR; Q5GAN6; -.
DR BioGRID; 130810; 10.
DR IntAct; Q5GAN6; 6.
DR STRING; 9606.ENSP00000333358; -.
DR BioMuta; RNASE10; -.
DR DMDM; 74741482; -.
DR jPOST; Q5GAN6; -.
DR MassIVE; Q5GAN6; -.
DR PaxDb; Q5GAN6; -.
DR PeptideAtlas; Q5GAN6; -.
DR PRIDE; Q5GAN6; -.
DR Antibodypedia; 22048; 25 antibodies from 8 providers.
DR DNASU; 338879; -.
DR Ensembl; ENST00000328444.5; ENSP00000333358.5; ENSG00000182545.6. [Q5GAN6-1]
DR Ensembl; ENST00000430083.1; ENSP00000392996.1; ENSG00000182545.6. [Q5GAN6-2]
DR GeneID; 338879; -.
DR KEGG; hsa:338879; -.
DR UCSC; uc001vxp.2; human. [Q5GAN6-1]
DR CTD; 338879; -.
DR GeneCards; RNASE10; -.
DR HGNC; HGNC:19275; RNASE10.
DR HPA; ENSG00000182545; Tissue enhanced (brain).
DR neXtProt; NX_Q5GAN6; -.
DR OpenTargets; ENSG00000182545; -.
DR PharmGKB; PA134878150; -.
DR VEuPathDB; HostDB:ENSG00000182545; -.
DR eggNOG; ENOG502RPGF; Eukaryota.
DR GeneTree; ENSGT00730000111443; -.
DR HOGENOM; CLU_1280301_0_0_1; -.
DR InParanoid; Q5GAN6; -.
DR PhylomeDB; Q5GAN6; -.
DR TreeFam; TF337410; -.
DR PathwayCommons; Q5GAN6; -.
DR SignaLink; Q5GAN6; -.
DR BioGRID-ORCS; 338879; 12 hits in 1061 CRISPR screens.
DR GenomeRNAi; 338879; -.
DR Pharos; Q5GAN6; Tdark.
DR PRO; PR:Q5GAN6; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q5GAN6; protein.
DR Bgee; ENSG00000182545; Expressed in bone marrow cell and 94 other tissues.
DR ExpressionAtlas; Q5GAN6; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0034113; P:heterotypic cell-cell adhesion; ISS:UniProtKB.
DR GO; GO:0022409; P:positive regulation of cell-cell adhesion; ISS:UniProtKB.
DR GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISS:UniProtKB.
DR GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR Gene3D; 3.10.130.10; -; 1.
DR InterPro; IPR029742; RNASE10.
DR InterPro; IPR001427; RNaseA.
DR InterPro; IPR036816; RNaseA-like_dom_sf.
DR InterPro; IPR023412; RNaseA_domain.
DR PANTHER; PTHR11437; PTHR11437; 1.
DR PANTHER; PTHR11437:SF2; PTHR11437:SF2; 1.
DR Pfam; PF00074; RnaseA; 1.
DR PRINTS; PR00794; RIBONUCLEASE.
DR SMART; SM00092; RNAse_Pc; 1.
DR SUPFAM; SSF54076; SSF54076; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell adhesion; Fertilization; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..216
FT /note="Inactive ribonuclease-like protein 10"
FT /id="PRO_0000045963"
FT REGION 43..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MWGAPLPRRPVWDVRSASAGPQPCLGGKM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053579"
FT VARIANT 131
FT /note="S -> N (in dbSNP:rs2067648)"
FT /id="VAR_052198"
SQ SEQUENCE 216 AA; 24008 MW; 0A6438BFDCA73271 CRC64;
MKLNLVQIFF MLLMLLLGLG MGLGLGLHMA TAVLEESDQP LNEFWSSDSQ DKAEATEEGD
GTQTTETLVL SNKEVVQPGW PEDPILGEDE VGGNKMLRAS ALFQSNKDYL RLDQTDRECN
DMMAHKMKEP SQSCIAQYAF IHEDLNTVKA VCNSPVIACE LKGGKCHKSS RPFDLTLCEL
SQPDQVTPNC NYLTSVIKKH IIITCNDMKR QLPTGQ
