ID   RNS10_RAT               Reviewed;         212 AA.
AC   Q5GAM0;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Inactive ribonuclease-like protein 10;
DE   AltName: Full=Protein Train A;
DE   Flags: Precursor;
GN   Name=Rnase10;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15676279; DOI=10.1016/j.ygeno.2004.10.008;
RA   Cho S., Beintema J.J., Zhang J.;
RT   "The ribonuclease A superfamily of mammals and birds: identifying new
RT   members and tracing evolutionary histories.";
RL   Genomics 85:208-220(2005).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=14561640; DOI=10.1095/biolreprod.103.022459;
RA   Castella S., Fouchecourt S., Teixeira-Gomes A.P., Vinh J., Belghazi M.,
RA   Dacheux F., Dacheux J.-L.;
RT   "Identification of a member of a new RNase A family specifically secreted
RT   by epididymal caput epithelium.";
RL   Biol. Reprod. 70:319-328(2004).
CC   -!- FUNCTION: Secreted proximal epididymal protein required for post-
CC       testicular sperm maturation and male fertility. May be involved in
CC       sperm adhesion to the egg zona pellucida. Does not have ribonuclease
CC       activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Male-specific expression in proximal caput of the
CC       epididymis. {ECO:0000269|PubMed:14561640}.
CC   -!- PTM: The N-terminus is blocked. Glycosylated (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000305}.
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DR   EMBL; AY665833; AAV87199.1; -; Genomic_DNA.
DR   RefSeq; NP_001012485.1; NM_001012467.1.
DR   AlphaFoldDB; Q5GAM0; -.
DR   SMR; Q5GAM0; -.
DR   STRING; 10116.ENSRNOP00000013619; -.
DR   GlyGen; Q5GAM0; 2 sites.
DR   PaxDb; Q5GAM0; -.
DR   GeneID; 305840; -.
DR   KEGG; rno:305840; -.
DR   UCSC; RGD:1310415; rat.
DR   CTD; 338879; -.
DR   RGD; 1310415; Rnase10.
DR   VEuPathDB; HostDB:ENSRNOG00000010261; -.
DR   eggNOG; ENOG502RPGF; Eukaryota.
DR   HOGENOM; CLU_1280301_0_0_1; -.
DR   InParanoid; Q5GAM0; -.
DR   OMA; GQVTPHC; -.
DR   OrthoDB; 1349885at2759; -.
DR   PhylomeDB; Q5GAM0; -.
DR   PRO; PR:Q5GAM0; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000010261; Expressed in spleen and 9 other tissues.
DR   ExpressionAtlas; Q5GAM0; baseline.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0003382; P:epithelial cell morphogenesis; ISO:RGD.
DR   GO; GO:0034113; P:heterotypic cell-cell adhesion; ISS:UniProtKB.
DR   GO; GO:0008584; P:male gonad development; ISO:RGD.
DR   GO; GO:0022409; P:positive regulation of cell-cell adhesion; ISS:UniProtKB.
DR   GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:0072520; P:seminiferous tubule development; ISO:RGD.
DR   GO; GO:0007338; P:single fertilization; ISO:RGD.
DR   Gene3D; 3.10.130.10; -; 1.
DR   InterPro; IPR029742; RNASE10.
DR   InterPro; IPR001427; RNaseA.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
DR   InterPro; IPR023412; RNaseA_domain.
DR   PANTHER; PTHR11437; PTHR11437; 1.
DR   PANTHER; PTHR11437:SF2; PTHR11437:SF2; 1.
DR   Pfam; PF00074; RnaseA; 1.
DR   PRINTS; PR00794; RIBONUCLEASE.
DR   SMART; SM00092; RNAse_Pc; 1.
DR   SUPFAM; SSF54076; SSF54076; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Fertilization; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..212
FT                   /note="Inactive ribonuclease-like protein 10"
FT                   /id="PRO_0000045966"
FT   CARBOHYD        129
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        204
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   212 AA;  23531 MW;  5D0F524D89AE5154 CRC64;
     MKVTLVHLLF MMLLLLLGLG VGLGLGLHMA AAILENQPLD EFWPSDSQDT AEATEEGQGT
     RTTEALVLDN KEMAVPVWSE DTVLSEDEVG GSRMLRAKTL LQSKQGYLKF DLNIRDCNVM
     MAHKIKEHNQ SCINDYTFIH EDPSTVGAVC NSPLVDCDLK GGKCHKSPRP FDLTLCKLAK
     PGQVTPNCHY LTYITEKVII ITCNNTKQLE IK