ID   RNS10_SHEEP             Reviewed;         212 AA.
AC   Q70IB1;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-JAN-2014, sequence version 2.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Inactive ribonuclease-like protein 10;
DE   AltName: Full=Protein Train A;
DE   Flags: Precursor;
GN   Name=RNASE10;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-161, AND TISSUE SPECIFICITY.
RC   TISSUE=Epididymis;
RX   PubMed=14561640; DOI=10.1095/biolreprod.103.022459;
RA   Castella S., Fouchecourt S., Teixeira-Gomes A.P., Vinh J., Belghazi M.,
RA   Dacheux F., Dacheux J.-L.;
RT   "Identification of a member of a new RNase A family specifically secreted
RT   by epididymal caput epithelium.";
RL   Biol. Reprod. 70:319-328(2004).
CC   -!- FUNCTION: Secreted proximal epididymal protein required for post-
CC       testicular sperm maturation and male fertility. May be involved in
CC       sperm adhesion to the egg zona pellucida. Does not have ribonuclease
CC       activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Male-specific expression in proximal caput of the
CC       epididymis. {ECO:0000269|PubMed:14561640}.
CC   -!- PTM: The N-terminus is blocked. Glycosylated (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AMGL01102297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJ580634; CAE45266.1; -; mRNA.
DR   AlphaFoldDB; Q70IB1; -.
DR   SMR; Q70IB1; -.
DR   STRING; 9940.ENSOARP00000021193; -.
DR   PRIDE; Q70IB1; -.
DR   eggNOG; ENOG502RPGF; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0034113; P:heterotypic cell-cell adhesion; ISS:UniProtKB.
DR   GO; GO:0022409; P:positive regulation of cell-cell adhesion; ISS:UniProtKB.
DR   GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.130.10; -; 1.
DR   InterPro; IPR029742; RNASE10.
DR   InterPro; IPR001427; RNaseA.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
DR   InterPro; IPR023412; RNaseA_domain.
DR   PANTHER; PTHR11437; PTHR11437; 1.
DR   PANTHER; PTHR11437:SF2; PTHR11437:SF2; 1.
DR   Pfam; PF00074; RnaseA; 1.
DR   PRINTS; PR00794; RIBONUCLEASE.
DR   SMART; SM00092; RNAse_Pc; 1.
DR   SUPFAM; SSF54076; SSF54076; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Fertilization; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..212
FT                   /note="Inactive ribonuclease-like protein 10"
FT                   /id="PRO_0000045967"
FT   CONFLICT        8
FT                   /note="I -> F (in Ref. 2; CAE45266)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   212 AA;  23486 MW;  B74807E22248D5C3 CRC64;
     MKLTLVQIFF MMLLLLLGLG VGLGLGLQMA AAVLEESDQL LDEFLSSDSQ DKAEATKEGL
     DSQSTETLLV SNKVVPPEDT IVNEDDVGGD RMLRAEVLSQ SNKHYLRSDV MDRECNALMA
     PNLKSKDHPC IPQYVFIHEE PDTVKAVCKS PAVACDLKEG KCHKSPRPFD LTFCKLSKSG
     QVIPHCNYVT FILEKYILMS CSDMKVQITS KS