RNS11_HUMAN
ID RNS11_HUMAN Reviewed; 199 AA.
AC Q8TAA1;
DT 30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Probable ribonuclease 11;
DE Short=RNase 11;
DE EC=3.1.27.-;
DE Flags: Precursor;
GN Name=RNASE11; Synonyms=C14orf6; ORFNames=UNQ5832/PRO19669;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TAA1; P32243-2: OTX2; NbExp=3; IntAct=EBI-13063024, EBI-9087860;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC {ECO:0000305}.
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DR EMBL; BX161458; CAD61920.1; -; mRNA.
DR EMBL; AK098687; BAC05378.1; -; mRNA.
DR EMBL; AY358794; AAQ89154.1; -; mRNA.
DR EMBL; BC025410; AAH25410.1; -; mRNA.
DR CCDS; CCDS9553.1; -.
DR RefSeq; NP_660293.1; NM_145250.3.
DR AlphaFoldDB; Q8TAA1; -.
DR SMR; Q8TAA1; -.
DR BioGRID; 125785; 2.
DR IntAct; Q8TAA1; 1.
DR STRING; 9606.ENSP00000451318; -.
DR GlyGen; Q8TAA1; 3 sites.
DR iPTMnet; Q8TAA1; -.
DR PhosphoSitePlus; Q8TAA1; -.
DR BioMuta; RNASE11; -.
DR DMDM; 31340020; -.
DR MassIVE; Q8TAA1; -.
DR PaxDb; Q8TAA1; -.
DR PeptideAtlas; Q8TAA1; -.
DR PRIDE; Q8TAA1; -.
DR ProteomicsDB; 73843; -.
DR Antibodypedia; 168; 214 antibodies from 23 providers.
DR DNASU; 122651; -.
DR Ensembl; ENST00000398008.6; ENSP00000381092.2; ENSG00000173464.14.
DR Ensembl; ENST00000398009.6; ENSP00000381093.2; ENSG00000173464.14.
DR Ensembl; ENST00000432835.6; ENSP00000395210.2; ENSG00000173464.14.
DR Ensembl; ENST00000553849.1; ENSP00000451318.1; ENSG00000173464.14.
DR Ensembl; ENST00000555841.5; ENSP00000451563.1; ENSG00000173464.14.
DR Ensembl; ENST00000620912.4; ENSP00000482059.1; ENSG00000173464.14.
DR GeneID; 122651; -.
DR KEGG; hsa:122651; -.
DR UCSC; uc010ahv.4; human.
DR CTD; 122651; -.
DR GeneCards; RNASE11; -.
DR HGNC; HGNC:19269; RNASE11.
DR HPA; ENSG00000173464; Tissue enriched (epididymis).
DR neXtProt; NX_Q8TAA1; -.
DR PharmGKB; PA134929509; -.
DR VEuPathDB; HostDB:ENSG00000173464; -.
DR eggNOG; ENOG502RR9B; Eukaryota.
DR GeneTree; ENSGT00510000049471; -.
DR HOGENOM; CLU_122912_0_0_1; -.
DR InParanoid; Q8TAA1; -.
DR OMA; WSNNFIH; -.
DR OrthoDB; 1392270at2759; -.
DR PhylomeDB; Q8TAA1; -.
DR TreeFam; TF341929; -.
DR PathwayCommons; Q8TAA1; -.
DR SignaLink; Q8TAA1; -.
DR BioGRID-ORCS; 122651; 5 hits in 1057 CRISPR screens.
DR GenomeRNAi; 122651; -.
DR Pharos; Q8TAA1; Tdark.
DR PRO; PR:Q8TAA1; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8TAA1; protein.
DR Bgee; ENSG00000173464; Expressed in left testis and 28 other tissues.
DR ExpressionAtlas; Q8TAA1; baseline.
DR Genevisible; Q8TAA1; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR Gene3D; 3.10.130.10; -; 1.
DR InterPro; IPR029743; RNASE11.
DR InterPro; IPR001427; RNaseA.
DR InterPro; IPR036816; RNaseA-like_dom_sf.
DR InterPro; IPR023412; RNaseA_domain.
DR PANTHER; PTHR11437; PTHR11437; 1.
DR PANTHER; PTHR11437:SF22; PTHR11437:SF22; 1.
DR Pfam; PF00074; RnaseA; 1.
DR SUPFAM; SSF54076; SSF54076; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Endonuclease; Glycoprotein; Hydrolase; Nuclease;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..199
FT /note="Probable ribonuclease 11"
FT /id="PRO_0000030908"
FT ACT_SITE 82
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 115..119
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..158
FT /evidence="ECO:0000250"
FT DISULFID 114..169
FT /evidence="ECO:0000250"
FT VARIANT 5
FT /note="P -> S (in dbSNP:rs17113756)"
FT /id="VAR_052195"
FT VARIANT 74
FT /note="T -> S (in dbSNP:rs35818240)"
FT /id="VAR_052196"
SQ SEQUENCE 199 AA; 22427 MW; BA9DBA907292F1F0 CRC64;
METFPLLLLS LGLVLAEASE STMKIIKEEF TDEEMQYDMA KSGQEKQTIE ILMNPILLVK
NTSLSMSKDD MSSTLLTFRS LHYNDPKGNS SGNDKECCND MTVWRKVSEA NGSCKWSNNF
IRSSTEVMRR VHRAPSCKFV QNPGISCCES LELENTVCQF TTGKQFPRCQ YHSVTSLEKI
LTVLTGHSLM SWLVCGSKL
