RNS11_MOUSE
ID RNS11_MOUSE Reviewed; 192 AA.
AC Q5GAM9; B9EJ01;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Putative inactive ribonuclease 11;
DE Short=RNase 11;
DE Flags: Precursor;
GN Name=Rnase11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15676279; DOI=10.1016/j.ygeno.2004.10.008;
RA Cho S., Beintema J.J., Zhang J.;
RT "The ribonuclease A superfamily of mammals and birds: identifying new
RT members and tracing evolutionary histories.";
RL Genomics 85:208-220(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC {ECO:0000305}.
CC -!- CAUTION: In contrast to other members of the family, lacks the
CC conserved His active site in position 75, suggesting it is inactive.
CC {ECO:0000305}.
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DR EMBL; AY665823; AAV87190.1; -; Genomic_DNA.
DR EMBL; AC136376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC141252; AAI41253.1; -; mRNA.
DR CCDS; CCDS27031.1; -.
DR RefSeq; NP_001011877.1; NM_001011877.2.
DR RefSeq; XP_006519283.1; XM_006519220.2.
DR RefSeq; XP_011243414.1; XM_011245112.1.
DR AlphaFoldDB; Q5GAM9; -.
DR STRING; 10090.ENSMUSP00000075472; -.
DR GlyGen; Q5GAM9; 2 sites.
DR iPTMnet; Q5GAM9; -.
DR PhosphoSitePlus; Q5GAM9; -.
DR PaxDb; Q5GAM9; -.
DR PRIDE; Q5GAM9; -.
DR ProteomicsDB; 260994; -.
DR Ensembl; ENSMUST00000076106; ENSMUSP00000075472; ENSMUSG00000059648.
DR GeneID; 497113; -.
DR KEGG; mmu:497113; -.
DR UCSC; uc007tmi.2; mouse.
DR CTD; 122651; -.
DR MGI; MGI:3528583; Rnase11.
DR VEuPathDB; HostDB:ENSMUSG00000059648; -.
DR eggNOG; ENOG502RR9B; Eukaryota.
DR GeneTree; ENSGT00940000168252; -.
DR HOGENOM; CLU_122912_0_0_1; -.
DR InParanoid; Q5GAM9; -.
DR OMA; WSNNFIH; -.
DR OrthoDB; 1392270at2759; -.
DR PhylomeDB; Q5GAM9; -.
DR TreeFam; TF341929; -.
DR BioGRID-ORCS; 497113; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q5GAM9; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q5GAM9; protein.
DR Bgee; ENSMUSG00000059648; Expressed in testis.
DR ExpressionAtlas; Q5GAM9; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR InterPro; IPR029743; RNASE11.
DR InterPro; IPR001427; RNaseA.
DR PANTHER; PTHR11437; PTHR11437; 1.
DR PANTHER; PTHR11437:SF22; PTHR11437:SF22; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..192
FT /note="Putative inactive ribonuclease 11"
FT /id="PRO_0000415815"
FT REGION 21..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 34
FT /note="M -> I (in Ref. 3; AAI41253)"
FT /evidence="ECO:0000305"
FT CONFLICT 100
FT /note="E -> K (in Ref. 3; AAI41253)"
FT /evidence="ECO:0000305"
FT CONFLICT 103
FT /note="G -> A (in Ref. 3; AAI41253)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 192 AA; 20883 MW; EDDBBA5A5BE540B9 CRC64;
MAVFLLLLAL GLLLAKPSES RMKGTTEQFS QEEMQPAAKQ TLEESANSTL SDKNTGLSIS
KHVMSATPLT PRRLSFIIPK GNTMRDGRNC VNSLRVWRTE VDGNASCQLG NDFIHGSMDV
SLRIPKATRG KCEQTPKPSS SGSLGLERTT CKVLAGHQCL RSHEHSITSL KKILTVLASN
SLMSWLVSGC KL
