ID   RNS12_HUMAN             Reviewed;         147 AA.
AC   Q5GAN4;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Probable inactive ribonuclease-like protein 12;
DE   Flags: Precursor;
GN   Name=RNASE12;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15676279; DOI=10.1016/j.ygeno.2004.10.008;
RA   Cho S., Beintema J.J., Zhang J.;
RT   "The ribonuclease A superfamily of mammals and birds: identifying new
RT   members and tracing evolutionary histories.";
RL   Genomics 85:208-220(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Does not exhibit any ribonuclease activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000305}.
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DR   EMBL; AY665807; AAV87185.1; -; mRNA.
DR   EMBL; BC130347; AAI30348.1; -; mRNA.
DR   EMBL; BC130349; AAI30350.1; -; mRNA.
DR   CCDS; CCDS32037.1; -.
DR   RefSeq; NP_001019993.1; NM_001024822.2.
DR   AlphaFoldDB; Q5GAN4; -.
DR   SMR; Q5GAN4; -.
DR   BioGRID; 138928; 2.
DR   STRING; 9606.ENSP00000450580; -.
DR   BioMuta; RNASE12; -.
DR   DMDM; 74741481; -.
DR   MassIVE; Q5GAN4; -.
DR   PaxDb; Q5GAN4; -.
DR   PeptideAtlas; Q5GAN4; -.
DR   PRIDE; Q5GAN4; -.
DR   Antibodypedia; 57709; 92 antibodies from 17 providers.
DR   DNASU; 493901; -.
DR   Ensembl; ENST00000556526.1; ENSP00000450580.1; ENSG00000258436.1.
DR   GeneID; 493901; -.
DR   KEGG; hsa:493901; -.
DR   CTD; 493901; -.
DR   DisGeNET; 493901; -.
DR   GeneCards; RNASE12; -.
DR   HGNC; HGNC:24211; RNASE12.
DR   HPA; ENSG00000258436; Tissue enriched (epididymis).
DR   neXtProt; NX_Q5GAN4; -.
DR   PharmGKB; PA134948996; -.
DR   VEuPathDB; HostDB:ENSG00000258436; -.
DR   eggNOG; ENOG502T3VJ; Eukaryota.
DR   GeneTree; ENSGT00730000111478; -.
DR   HOGENOM; CLU_117006_1_0_1; -.
DR   InParanoid; Q5GAN4; -.
DR   OMA; ACRYHIS; -.
DR   OrthoDB; 1549558at2759; -.
DR   PhylomeDB; Q5GAN4; -.
DR   TreeFam; TF333393; -.
DR   PathwayCommons; Q5GAN4; -.
DR   SignaLink; Q5GAN4; -.
DR   BioGRID-ORCS; 493901; 11 hits in 1027 CRISPR screens.
DR   GenomeRNAi; 493901; -.
DR   Pharos; Q5GAN4; Tdark.
DR   PRO; PR:Q5GAN4; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; Q5GAN4; protein.
DR   Bgee; ENSG00000258436; Expressed in placenta and 7 other tissues.
DR   ExpressionAtlas; Q5GAN4; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004540; F:ribonuclease activity; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   Gene3D; 3.10.130.10; -; 1.
DR   InterPro; IPR029740; RNASE12.
DR   InterPro; IPR001427; RNaseA.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
DR   InterPro; IPR023412; RNaseA_domain.
DR   PANTHER; PTHR11437; PTHR11437; 1.
DR   PANTHER; PTHR11437:SF20; PTHR11437:SF20; 1.
DR   Pfam; PF00074; RnaseA; 1.
DR   PRINTS; PR00794; RIBONUCLEASE.
DR   SMART; SM00092; RNAse_Pc; 1.
DR   SUPFAM; SSF54076; SSF54076; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..147
FT                   /note="Probable inactive ribonuclease-like protein 12"
FT                   /id="PRO_0000308702"
SQ   SEQUENCE   147 AA;  17177 MW;  12BFEF88AE8EB08C CRC64;
     MIIMVIIFLV LLFWENEVND EAVMSTLEHL HVDYPQNDVP VPARYCNHMI IQRVIREPDH
     TCKKEHVFIH ERPRKINGIC ISPKKVACQN LSAIFCFQSE TKFKMTVCQL IEGTRYPACR
     YHYSPTEGFV LVTCDDLRPD SFLGYVK