RNS12_MOUSE
ID RNS12_MOUSE Reviewed; 145 AA.
AC Q5GAM8;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Probable inactive ribonuclease-like protein 12;
DE Flags: Precursor;
GN Name=Rnase12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=15676279; DOI=10.1016/j.ygeno.2004.10.008;
RA Cho S., Beintema J.J., Zhang J.;
RT "The ribonuclease A superfamily of mammals and birds: identifying new
RT members and tracing evolutionary histories.";
RL Genomics 85:208-220(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Does not exhibit any ribonuclease activity. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC {ECO:0000305}.
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DR EMBL; AY665824; AAV87191.1; -; Genomic_DNA.
DR EMBL; BC146014; AAI46015.1; -; mRNA.
DR EMBL; BC146016; AAI46017.1; -; mRNA.
DR CCDS; CCDS27032.1; -.
DR RefSeq; NP_001011875.1; NM_001011875.2.
DR AlphaFoldDB; Q5GAM8; -.
DR SMR; Q5GAM8; -.
DR PaxDb; Q5GAM8; -.
DR PRIDE; Q5GAM8; -.
DR ProteomicsDB; 260825; -.
DR Antibodypedia; 57709; 92 antibodies from 17 providers.
DR DNASU; 497106; -.
DR Ensembl; ENSMUST00000089798; ENSMUSP00000087231; ENSMUSG00000068407.
DR Ensembl; ENSMUST00000227764; ENSMUSP00000154201; ENSMUSG00000068407.
DR GeneID; 497106; -.
DR KEGG; mmu:497106; -.
DR UCSC; uc007tmj.2; mouse.
DR CTD; 493901; -.
DR MGI; MGI:3528588; Rnase12.
DR VEuPathDB; HostDB:ENSMUSG00000068407; -.
DR eggNOG; ENOG502T3VJ; Eukaryota.
DR GeneTree; ENSGT00730000111478; -.
DR HOGENOM; CLU_117006_1_0_1; -.
DR InParanoid; Q5GAM8; -.
DR OMA; ACRYHIS; -.
DR OrthoDB; 1549558at2759; -.
DR PhylomeDB; Q5GAM8; -.
DR TreeFam; TF333393; -.
DR BioGRID-ORCS; 497106; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q5GAM8; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q5GAM8; protein.
DR Bgee; ENSMUSG00000068407; Expressed in morula and 28 other tissues.
DR ExpressionAtlas; Q5GAM8; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004540; F:ribonuclease activity; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR Gene3D; 3.10.130.10; -; 1.
DR InterPro; IPR029740; RNASE12.
DR InterPro; IPR001427; RNaseA.
DR InterPro; IPR036816; RNaseA-like_dom_sf.
DR InterPro; IPR023412; RNaseA_domain.
DR PANTHER; PTHR11437; PTHR11437; 1.
DR PANTHER; PTHR11437:SF20; PTHR11437:SF20; 1.
DR Pfam; PF00074; RnaseA; 1.
DR PRINTS; PR00794; RIBONUCLEASE.
DR SMART; SM00092; RNAse_Pc; 1.
DR SUPFAM; SSF54076; SSF54076; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..145
FT /note="Probable inactive ribonuclease-like protein 12"
FT /id="PRO_0000308703"
SQ SEQUENCE 145 AA; 16936 MW; 723032269725AD05 CRC64;
MVLMVVVFLL LLFWENELTE DVVLTSIEQL HVDYPQNAVP LRYCNYMILQ RVIREPDHRC
RKVHVFIHER PQKINRVCTS SKKMSCPNDS DLFCFQSETK FRMTVCQLID GTTYPACRYQ
ISPIKGFVLV TCDDLGPVDL QGYVE
