ID   RNS12_RAT               Reviewed;         145 AA.
AC   Q5GAL8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Probable inactive ribonuclease-like protein 12;
DE   Flags: Precursor;
GN   Name=Rnase12;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15676279; DOI=10.1016/j.ygeno.2004.10.008;
RA   Cho S., Beintema J.J., Zhang J.;
RT   "The ribonuclease A superfamily of mammals and birds: identifying new
RT   members and tracing evolutionary histories.";
RL   Genomics 85:208-220(2005).
CC   -!- FUNCTION: Does not exhibit any ribonuclease activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000305}.
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DR   EMBL; AY665835; AAV87201.1; -; Genomic_DNA.
DR   RefSeq; NP_001012209.1; NM_001012209.1.
DR   RefSeq; XP_008768779.1; XM_008770557.1.
DR   RefSeq; XP_008768780.1; XM_008770558.2.
DR   RefSeq; XP_017455250.1; XM_017599761.1.
DR   AlphaFoldDB; Q5GAL8; -.
DR   SMR; Q5GAL8; -.
DR   GlyGen; Q5GAL8; 1 site.
DR   PaxDb; Q5GAL8; -.
DR   Ensembl; ENSRNOT00000064936; ENSRNOP00000060090; ENSRNOG00000042612.
DR   GeneID; 364302; -.
DR   KEGG; rno:364302; -.
DR   UCSC; RGD:1307829; rat.
DR   CTD; 493901; -.
DR   RGD; 1307829; Rnase12.
DR   eggNOG; ENOG502T3VJ; Eukaryota.
DR   GeneTree; ENSGT00730000111478; -.
DR   HOGENOM; CLU_117006_1_0_1; -.
DR   InParanoid; Q5GAL8; -.
DR   OMA; ACRYHIS; -.
DR   OrthoDB; 1549558at2759; -.
DR   PhylomeDB; Q5GAL8; -.
DR   TreeFam; TF333393; -.
DR   PRO; PR:Q5GAL8; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000042612; Expressed in testis and 4 other tissues.
DR   ExpressionAtlas; Q5GAL8; baseline and differential.
DR   Genevisible; Q5GAL8; RN.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004540; F:ribonuclease activity; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   Gene3D; 3.10.130.10; -; 1.
DR   InterPro; IPR029740; RNASE12.
DR   InterPro; IPR001427; RNaseA.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
DR   InterPro; IPR023412; RNaseA_domain.
DR   PANTHER; PTHR11437; PTHR11437; 1.
DR   PANTHER; PTHR11437:SF20; PTHR11437:SF20; 1.
DR   Pfam; PF00074; RnaseA; 1.
DR   PRINTS; PR00794; RIBONUCLEASE.
DR   SMART; SM00092; RNAse_Pc; 1.
DR   SUPFAM; SSF54076; SSF54076; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..145
FT                   /note="Probable inactive ribonuclease-like protein 12"
FT                   /id="PRO_0000308704"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   145 AA;  16976 MW;  35DFF9DCF4BCEAA7 CRC64;
     MILMVIVFLL LLFWENELTE DVVLTSMEHL HVDYPQSAVP LRYCNYMILQ RVIREPDYTC
     RKVHVFIHER PQKINRICTS SKKMTCPNYS EIFCFQSDTK FRMTVCQLTG GSKYPACRYQ
     ISPTEGFVLV TCDDLGPVNF QGYVE