ID   RNS13_HUMAN             Reviewed;         156 AA.
AC   Q5GAN3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Probable inactive ribonuclease-like protein 13;
DE   Flags: Precursor;
GN   Name=RNASE13;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15676279; DOI=10.1016/j.ygeno.2004.10.008;
RA   Cho S., Beintema J.J., Zhang J.;
RT   "The ribonuclease A superfamily of mammals and birds: identifying new
RT   members and tracing evolutionary histories.";
RL   Genomics 85:208-220(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Does not exhibit any ribonuclease activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000305}.
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DR   EMBL; AY665808; AAV87186.1; -; mRNA.
DR   EMBL; BC044831; AAH44831.1; -; mRNA.
DR   CCDS; CCDS32039.1; -.
DR   RefSeq; NP_001012264.1; NM_001012264.3.
DR   AlphaFoldDB; Q5GAN3; -.
DR   SMR; Q5GAN3; -.
DR   BioGRID; 136351; 33.
DR   IntAct; Q5GAN3; 6.
DR   STRING; 9606.ENSP00000372410; -.
DR   GlyGen; Q5GAN3; 1 site.
DR   iPTMnet; Q5GAN3; -.
DR   PhosphoSitePlus; Q5GAN3; -.
DR   BioMuta; RNASE13; -.
DR   DMDM; 74741480; -.
DR   MassIVE; Q5GAN3; -.
DR   PaxDb; Q5GAN3; -.
DR   PeptideAtlas; Q5GAN3; -.
DR   PRIDE; Q5GAN3; -.
DR   ProteomicsDB; 62823; -.
DR   Antibodypedia; 47225; 98 antibodies from 17 providers.
DR   DNASU; 440163; -.
DR   Ensembl; ENST00000382951.4; ENSP00000372410.3; ENSG00000206150.4.
DR   GeneID; 440163; -.
DR   KEGG; hsa:440163; -.
DR   MANE-Select; ENST00000382951.4; ENSP00000372410.3; NM_001012264.4; NP_001012264.1.
DR   CTD; 440163; -.
DR   DisGeNET; 440163; -.
DR   GeneCards; RNASE13; -.
DR   HGNC; HGNC:25285; RNASE13.
DR   HPA; ENSG00000206150; Tissue enriched (epididymis).
DR   neXtProt; NX_Q5GAN3; -.
DR   PharmGKB; PA134922548; -.
DR   VEuPathDB; HostDB:ENSG00000206150; -.
DR   eggNOG; ENOG502SRBA; Eukaryota.
DR   GeneTree; ENSGT00390000015830; -.
DR   HOGENOM; CLU_1685971_0_0_1; -.
DR   InParanoid; Q5GAN3; -.
DR   OMA; GYCNGLM; -.
DR   OrthoDB; 1461382at2759; -.
DR   PhylomeDB; Q5GAN3; -.
DR   TreeFam; TF343810; -.
DR   PathwayCommons; Q5GAN3; -.
DR   SignaLink; Q5GAN3; -.
DR   BioGRID-ORCS; 440163; 6 hits in 1060 CRISPR screens.
DR   GenomeRNAi; 440163; -.
DR   Pharos; Q5GAN3; Tbio.
DR   PRO; PR:Q5GAN3; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; Q5GAN3; protein.
DR   Bgee; ENSG00000206150; Expressed in right lobe of liver and 47 other tissues.
DR   ExpressionAtlas; Q5GAN3; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   Gene3D; 3.10.130.10; -; 1.
DR   InterPro; IPR029739; RNASE13.
DR   InterPro; IPR001427; RNaseA.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
DR   InterPro; IPR023412; RNaseA_domain.
DR   PANTHER; PTHR11437; PTHR11437; 1.
DR   PANTHER; PTHR11437:SF11; PTHR11437:SF11; 1.
DR   Pfam; PF00074; RnaseA; 1.
DR   SUPFAM; SSF54076; SSF54076; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..156
FT                   /note="Probable inactive ribonuclease-like protein 13"
FT                   /id="PRO_0000308705"
FT   CARBOHYD        126
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         139
FT                   /note="S -> A (in dbSNP:rs2277847)"
FT                   /id="VAR_036874"
SQ   SEQUENCE   156 AA;  17845 MW;  A842A361064ADD2E CRC64;
     MAPAVTRLLF LQLVLGPTLV MDIKMQIGSR NFYTLSIDYP RVNYPKGFRG YCNGLMSYMR
     GKMQNSDCPK IHYVIHAPWK AIQKFCKYSD SFCENYNEYC TLTQDSLPIT VCSLSHQQPP
     TSCYYNSTLT NQKLYLLCSR KYEADPIGIA GLYSGI