ID   RNS2_PANGI              Reviewed;         153 AA.
AC   P80890;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Ribonuclease 2;
DE            EC=3.1.-.-;
OS   Panax ginseng (Korean ginseng).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Apiales; Araliaceae; Panax.
OX   NCBI_TaxID=4054;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=cv. R1; TISSUE=Callus;
RX   PubMed=9166900; DOI=10.1016/s0014-5793(97)00337-2;
RA   Moiseyev G.P., Fedoreyeva L.I., Zhuravlev Y.N., Yasnetskaya E.G.,
RA   Jekel P.A., Beintema J.J.;
RT   "Primary structures of two ribonucleases from ginseng calluses. New members
RT   of the PR-10 family of intracellular pathogenesis-related plant proteins.";
RL   FEBS Lett. 407:207-210(1997).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-21.
RC   TISSUE=Root;
RX   PubMed=12362331;
RX   DOI=10.1002/1615-9861(200209)2:9<1123::aid-prot1123>3.0.co;2-s;
RA   Lum J.H.-K., Fung K.-L., Cheung P.-Y., Wong M.-S., Lee C.-H., Kwok F.S.-L.,
RA   Leung M.C.-P., Hui P.-K., Lo S.C.-L.;
RT   "Proteome of oriental ginseng Panax ginseng C. A. Meyer and the potential
RT   to use it as an identification tool.";
RL   Proteomics 2:1123-1130(2002).
CC   -!- FUNCTION: Catalyzes the two-stage endonucleolytic cleavage to 3'-
CC       phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic
CC       phosphate intermediates.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BetVI family. {ECO:0000305}.
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DR   AlphaFoldDB; P80890; -.
DR   SMR; P80890; -.
DR   Allergome; 10131; Pan g 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0010427; F:abscisic acid binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR000916; Bet_v_I/MLP.
DR   InterPro; IPR024949; Bet_v_I_allergen.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF00407; Bet_v_1; 1.
DR   PRINTS; PR00634; BETALLERGEN.
DR   SMART; SM01037; Bet_v_1; 1.
DR   PROSITE; PS00451; PATHOGENESIS_BETVI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Endonuclease; Hydrolase; Nuclease;
KW   Pathogenesis-related protein; Plant defense.
FT   CHAIN           1..153
FT                   /note="Ribonuclease 2"
FT                   /id="PRO_0000154156"
FT   CONFLICT        20
FT                   /note="K -> I (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   153 AA;  16492 MW;  2E799763E4487E9A CRC64;
     GVQKTETQAI SPVPAEKLFK GSFLDMDTVV PKAFPEGIKS VQVLEGNGGV GTIKNVTLGD
     ATPFNTMKTR IDAIDEHAFT YTYTIIGGDI LLDIIESIEN HFKIVPTDGG STITQTTIYN
     TIGDAVIPEE NIKDATDKSI QLFKAVEAYL LAN