ID   RNTF_MYCTA              Reviewed;         449 AA.
AC   A5U6X0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=PGL/p-HBAD biosynthesis rhamnosyltransferase;
DE            EC=2.4.1.-;
GN   OrderedLocusNames=MRA_2989;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- FUNCTION: Catalyzes the transfer of the first rhamnosyl residue on p-
CC       hydroxybenzoic acid or phenolphthiocerol derivatives to form, after O-
CC       methylation at position 2 of the sugar unit, mono-O-methyl-glycosyl-p-
CC       hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-rhamnosyl-
CC       phenolphthiocerol dimycocerosate (also called mycoside B) during p-
CC       hydroxybenzoic acid derivatives (p-HBAD) and glycosylated
CC       phenolphthiocerol dimycocerosates (PGL) biosynthesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 28 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000611; ABQ74770.1; -; Genomic_DNA.
DR   RefSeq; WP_003414922.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U6X0; -.
DR   SMR; A5U6X0; -.
DR   STRING; 419947.MRA_2989; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   EnsemblBacteria; ABQ74770; ABQ74770; MRA_2989.
DR   KEGG; mra:MRA_2989; -.
DR   eggNOG; COG1819; Bacteria.
DR   HOGENOM; CLU_692271_0_0_11; -.
DR   OMA; WNIEECV; -.
DR   OrthoDB; 1485440at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0016758; F:hexosyltransferase activity; IEA:UniProt.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   Pfam; PF00201; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Transferase.
FT   CHAIN           1..449
FT                   /note="PGL/p-HBAD biosynthesis rhamnosyltransferase"
FT                   /id="PRO_0000313793"
SQ   SEQUENCE   449 AA;  49433 MW;  205FDB0855C0A109 CRC64;
     MRVSCVYATA SRWGGPPVAS EVRGDAAIST TPDAAPGLAA RRRRILFVAE AVTLAHVVRP
     FALAQSLDPS RYEVHFACDP RYNQLLGPLP FRHHAIHTIP SERFFGNLTQ GRFYAMRTLR
     KYVEADLRVL DEIAPDLVVG DLRISLSVSA RLAGIPYIAI ANAYWSPYAQ RRFPLPDVIW
     TRLFGVRLVK LLYRLERPLL FALQCMPLNW VRRRHGLSSL GWNLCRIFTD GDHTLYADVP
     ELMPTYDLPA NHEYLGPVLW SPAGKPPTWW DSLPTDRPIV YATLGTSGGR NLLQLVLNAL
     AELPVTVIAA TAGRSDLKTV PANAFVADYL PGEAAAARSA VVVCNGGSLT TQQALVAGVP
     VIGVAGNLDQ HLNMEAVERA GAGVLLRTER LKSQRVAGAV MQVISRSEYR QAAARLADAF
     GRDRVGFPQH VENALRLMPE NRPRTWLAS