ID   RNY2_LEVBA              Reviewed;         535 AA.
AC   Q03NQ6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Ribonuclease Y 2 {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y 2 {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny2 {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=LVIS_2112;
OS   Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM
OS   1170 / LMG 11437 / NCIMB 947 / NCTC 947) (Lactobacillus brevis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Levilactobacillus.
OX   NCBI_TaxID=387344;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB
RC   947 / NCTC 947;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; CP000416; ABJ65166.1; -; Genomic_DNA.
DR   RefSeq; WP_011668889.1; NC_008497.1.
DR   AlphaFoldDB; Q03NQ6; -.
DR   SMR; Q03NQ6; -.
DR   STRING; 387344.LVIS_2112; -.
DR   EnsemblBacteria; ABJ65166; ABJ65166; LVIS_2112.
DR   KEGG; lbr:LVIS_2112; -.
DR   eggNOG; COG1418; Bacteria.
DR   HOGENOM; CLU_028328_1_0_9; -.
DR   OMA; THVELGV; -.
DR   OrthoDB; 1012190at2; -.
DR   Proteomes; UP000001652; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW   Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT   CHAIN           1..535
FT                   /note="Ribonuclease Y 2"
FT                   /id="PRO_0000344890"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          207..268
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          334..427
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   535 AA;  59402 MW;  EDE531397DD90F51 CRC64;
     MLITGLIIGC LLIGLVIGYV VRQHQHRQEL LAVQKQARDI IASATAETQQ KIAKLTADSR
     RETLTYQQSV KDELAEQTSD IAVREQRRQQ REQLLGQMGV RLADQTAILD ERSQANRDQR
     QKIRDLKAQA LQLRTDRDEM LAQQAGIDEQ AAKDHVLADT ELDLKRDRDV EIKALNDNAV
     ANAERWAKDV VLSATESGPQ DLPKEHLEHT VTVPNGEIRS KIIGRDGQHI RLLETLTGTD
     LIFVPDDNTT LFISTHDPIR REVARVALTN LVASRRISSN QIETQVENAQ RDVNHSLWET
     GEQTVSGLHV GWMHPDLMKL IGRLKYRTSY GQNVLLHSIE VAQLTGAMAA RLGYNTRLAR
     RAGLLHDLGK AIDHEVEGTH VEIGTEFAQK YGEDDVVINA IAAHHGDVEK TSPLAELVAA
     ADAISGARPG ARSESVEDYI NRLRALEKIA NDQSGVAESY AIQAGRELRI IVKPQELDDT
     AAANLTQEVA QQIESTLTYP GKIKVTTIRK STAVEYVGDE KKKKSKKKKK KAANA