ID   RNY_BACFR               Reviewed;         511 AA.
AC   Q64Q86;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=BF3602;
OS   Bacteroides fragilis (strain YCH46).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=295405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YCH46;
RX   PubMed=15466707; DOI=10.1073/pnas.0404172101;
RA   Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N.,
RA   Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
RT   "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions
RT   regulating cell surface adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; AP006841; BAD50345.1; -; Genomic_DNA.
DR   RefSeq; WP_005790424.1; NZ_UYXF01000009.1.
DR   RefSeq; YP_100879.1; NC_006347.1.
DR   AlphaFoldDB; Q64Q86; -.
DR   SMR; Q64Q86; -.
DR   STRING; 295405.BF3602; -.
DR   PRIDE; Q64Q86; -.
DR   EnsemblBacteria; BAD50345; BAD50345; BF3602.
DR   GeneID; 66331749; -.
DR   KEGG; bfr:BF3602; -.
DR   PATRIC; fig|295405.11.peg.3459; -.
DR   HOGENOM; CLU_028328_1_0_10; -.
DR   OMA; PHAILGM; -.
DR   Proteomes; UP000002197; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease; RNA-binding;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..511
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000344824"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          201..261
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          327..420
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   511 AA;  57195 MW;  64403B5E84DBCBAA CRC64;
     MLVTIVASIA CFIVGGILSY VLFKYGLKAK YDNVLKEAET EAEVIKKNKL LEVKEKFLNK
     KADLEKEVAL RNQKIQQAEN KLKQREMVLS QRQEEIQRKR AEADAVRENL EAQLGIVDKK
     KEELDKLQHQ EIEKLEALSG LSADEAKERL VESLKEEAKT QAQSYINDIM DDAKLTASKE
     AKRIVIQSIQ RVATETAIEN SVTVFHIESD EIKGRIIGRE GRNIRALEAA TGVEIVVDDT
     PEAIVLSAFD PVRREIARLA LHQLVTDGRI HPARIEEVVA KVRKQVEEEI IETGKRTTID
     LGIHGLHPEL IRIIGKMKYR SSYGQNLLQH ARETANLCAV MASELGLNPK KAKRAGLLHD
     IGKVPDEEPE LPHALLGMKL AEKFKEKPDI CNAIGAHHDE IEMTSLLAPI VQVCDAISGA
     RPGARREIVE AYIKRLNDLE QLAMSYPGVT KTYAIQAGRE LRVIVGADKI DDKQTENLSG
     EIAKKIQDEM TYPGQVKITV IRETRAVSFA K