ID   RNY_BACTN               Reviewed;         511 AA.
AC   Q89ZG0;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=BT_4417;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; AE015928; AAO79522.1; -; Genomic_DNA.
DR   RefSeq; NP_813328.1; NC_004663.1.
DR   RefSeq; WP_008760083.1; NZ_UYXG01000010.1.
DR   AlphaFoldDB; Q89ZG0; -.
DR   SMR; Q89ZG0; -.
DR   STRING; 226186.BT_4417; -.
DR   PaxDb; Q89ZG0; -.
DR   PRIDE; Q89ZG0; -.
DR   DNASU; 1073004; -.
DR   EnsemblBacteria; AAO79522; AAO79522; BT_4417.
DR   GeneID; 60925593; -.
DR   KEGG; bth:BT_4417; -.
DR   PATRIC; fig|226186.12.peg.4497; -.
DR   eggNOG; COG1418; Bacteria.
DR   HOGENOM; CLU_028328_1_0_10; -.
DR   InParanoid; Q89ZG0; -.
DR   OMA; PHAILGM; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW   Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT   CHAIN           1..511
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000163766"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          201..261
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          327..420
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   511 AA;  57199 MW;  B38C16A7C02AA9F8 CRC64;
     MIAIIATAIA CFVVGGILSY VLFRYVLKSK YDSVLKDAET EAEVIKKNKL LEVKEKFLNK
     KADLEKEVAL RNQKIQQAEN KLKQREMVLS QRQEEIQRKK LEAEAVKENL EAQLVIVDKK
     KEELDKLQHQ EIEKLEAISG LSADEAKERL VESLKEEAKT QAQSFINDIM DDAKLTASKE
     AKRIVIQSIQ RVATETAIEN SVTVFHIESD EIKGRIIGRE GRNIRALEAA TGVEIVVDDT
     PEAIVLSAFD PVRREIARLA LHQLVTDGRI HPARIEEVVS KVRKQVEEEI IETGKRTTID
     LGIHGLHPEL IRIIGKMKYR SSYGQNLLQH ARETANLCAV MASELGLNPK KAKRAGLLHD
     IGKVPDEEPE LPHALLGMKL AEKYKEKPDI CNAIGAHHDE TEMTSLLAPI VQVCDAISGA
     RPGARREIVE AYIKRLNDLE QLAMAYPGVT KTYAIQAGRE LRVIVGADKI DDKQTESLSG
     EIAKKIQDEM TYPGQVKITV IRETRAVSFA K