ID   RNY_BORBU               Reviewed;         510 AA.
AC   O51457;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=BB_0504;
OS   Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS   (Borrelia burgdorferi).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=224326;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=9403685; DOI=10.1038/37551;
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA   Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA   Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA   van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA   Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA   Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA   Smith H.O., Venter J.C.;
RT   "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL   Nature 390:580-586(1997).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; AE000783; AAC66875.1; -; Genomic_DNA.
DR   PIR; G70162; G70162.
DR   RefSeq; NP_212638.1; NC_001318.1.
DR   RefSeq; WP_002656978.1; NC_001318.1.
DR   AlphaFoldDB; O51457; -.
DR   SMR; O51457; -.
DR   STRING; 224326.BB_0504; -.
DR   PRIDE; O51457; -.
DR   DNASU; 1195350; -.
DR   EnsemblBacteria; AAC66875; AAC66875; BB_0504.
DR   GeneID; 56567939; -.
DR   KEGG; bbu:BB_0504; -.
DR   PATRIC; fig|224326.49.peg.895; -.
DR   HOGENOM; CLU_028328_1_0_12; -.
DR   OMA; PHAILGM; -.
DR   Proteomes; UP000001807; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW   Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT   CHAIN           1..510
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000163767"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          198..258
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          324..419
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   510 AA;  58003 MW;  A85D675FEA63C668 CRC64;
     MIYIIFSSIF AGFILGFLVR VFLGRLSLLD LEKNLKKVRV ESQLEIENER RQIIANAKSQ
     MLKEKNQQDR DIRDRKNEIV NLEKRLLQRE ETLDKRISAL DKQQSRVDFK IKEFEQKEKV
     IREKEADLVK RLENISGLTR EDARKIVIEK VEHESKRDAQ VIINKSEQEA QLLADKVAKD
     ILVSTMQRIV TEVSSEFTVA SVELPNDEMK GRIIGKEGRN IRALETLIGA DIIIDDTPEA
     VVISCFDPIR KELAKRTLER LVTDGRIHPA RIEEVVYNVT NEINSIIQEE GEKVVFDLNI
     HGLDKRLIRG LGRLYFRSSY GQNVLSHSKE TAIIGEILAK EMKLDPVVVK RACLLHDIGK
     GMESISDNSE GHAITGAELA QSCGESEIVV NAIAAHHNEV KPESLEAIVV QIADAISASR
     PGARRESLNN YINRLKRLED IAYSFEGVQK CYAIQAGREV RIIVDNALIN DEKSILLARD
     IAKKIEAEMR YPGKIKVTII RETRVIEYAR