ID   RNY_CAMC1               Reviewed;         517 AA.
AC   A7ZDR5;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=Ccon26_10650;
GN   ORFNames=CCC13826_1309;
OS   Campylobacter concisus (strain 13826).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=360104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13826;
RA   Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G.,
RA   Mandrell R.E., On S., Nelson K.E.;
RT   "Genome sequence of Campylobacter concisus 13826 isolated from human
RT   feces.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAT97318.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000792; EAT97318.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_034901872.1; NC_009802.2.
DR   AlphaFoldDB; A7ZDR5; -.
DR   SMR; A7ZDR5; -.
DR   STRING; 360104.CCC13826_1309; -.
DR   EnsemblBacteria; EAT97318; EAT97318; CCC13826_1309.
DR   KEGG; cco:CCC13826_1309; -.
DR   eggNOG; COG1418; Bacteria.
DR   HOGENOM; CLU_028328_1_0_7; -.
DR   OrthoDB; 1012190at2; -.
DR   Proteomes; UP000001121; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease; RNA-binding;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..517
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000344832"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          207..273
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          333..426
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   517 AA;  57753 MW;  B0BF70D49E378D3E CRC64;
     MIEVLIGLGA GVVGVGAGYL YAKKINDANY NIFLEQAKAK AKAIEYEAEL TLKNSKISVQ
     EAEFEAKKRY DDKTTKLQKE YASKFDELTK KEKILLNEQE LLNESKELFE KDKQDAKVTY
     EEGLNLKATY QNKVEEAIRV LEHAAGLTEE EAKEVVLKKV EEKSRADIAH IVRKYEEEAK
     REAKKRVNYI LAQATSRFAG EFAAERLINV VNIKNDELKG RIIGKEGRNI KTLEMVLGVD
     IIIDDTPHAI ILSSFNLYRR AIATRVIELL VEDGRIQPAR IEDLHKKVTE EFEQSIQEEG
     ENIVMDLGLN KIHPEIVKLI GKLKFRASYG QNALAHSLEV AHLAGIIAAE CGGDEKLAKR
     AGILHDIGKA LTHEYEGSHV DLGAEICKRY KEHPVVINAI YAHHGHEEAT SIESAAVCAA
     DALSAARPGA RREVLESFLK RVEEIENIAK SKEGIKQAYA INAGREIRVI ANAKLINDDE
     AVLVAKEIAQ EIESKVQYPG EIKVSVIRET RAVDFAK