ID   RNY_CAMC5               Reviewed;         517 AA.
AC   A7GY23;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=Ccur92_08110;
GN   ORFNames=CCV52592_1398;
OS   Campylobacter curvus (strain 525.92).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=360105;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=525.92;
RA   Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G.,
RA   Mandrell R.E., Lastovica A.J., Nelson K.E.;
RT   "Genome sequence of Campylobacter curvus 525.92 isolated from human
RT   feces.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAU00478.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000767; EAU00478.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_034966560.1; NC_009715.2.
DR   AlphaFoldDB; A7GY23; -.
DR   STRING; 360105.CCV52592_1398; -.
DR   PRIDE; A7GY23; -.
DR   EnsemblBacteria; EAU00478; EAU00478; CCV52592_1398.
DR   KEGG; ccv:CCV52592_1398; -.
DR   HOGENOM; CLU_028328_1_0_7; -.
DR   OrthoDB; 1012190at2; -.
DR   Proteomes; UP000006380; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW   Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT   CHAIN           1..517
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000344833"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          207..273
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          333..426
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   517 AA;  57797 MW;  E9891F7D552A9B1B CRC64;
     MIEVLIGLGA GVAGVGAGYL YAKKINDANY NIFLEQAKAK AKAIEYEAEL TLKNSKISVQ
     EAEFEAKKRY DDKTTKLQKE YSQKFDELNK KEQILLNEQE LLNENKELFE KDRNEAKLTY
     EEGLNLKATY QSKVQEALKV LEHAAGLTED EAREVVLKKV EEKSRADIAH IVRKHEEEAK
     REAKKRVNYI LAQATSRFAG EFAAERLINV VNIKNDELKG RIIGKEGRNI KTLEMVLGVD
     IIIDDTPHAI ILSSFNLYRR AIATRVIELL VEDGRIQPAR IEDLHKKVTE EFEQSIQEEG
     ENIVIDLGLS KIHPEITKLI GKLKFRASYG QNALAHSLEV AHLAGIIAAE TGGDEKLAKR
     AGLLHDIGKA LTHEFEGSHV DLGAEICKRY KEHPVVINAI YAHHGHEEAT SIESAAVCAA
     DCLSAARPGA RREVLESFLK RVEEVENIAK SKDGIKQAYA INAGREIRVI ANAKLINDDE
     AVLVAKEIAK EIEEKVQYPG EIKVSVIRET RAVDYAK