ID   RNY_CAMJE               Reviewed;         517 AA.
AC   Q9PN86; Q0P947;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=Cj1209;
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; AL111168; CAL35324.1; -; Genomic_DNA.
DR   PIR; C81327; C81327.
DR   RefSeq; WP_002858133.1; NC_002163.1.
DR   RefSeq; YP_002344600.1; NC_002163.1.
DR   AlphaFoldDB; Q9PN86; -.
DR   IntAct; Q9PN86; 42.
DR   STRING; 192222.Cj1209; -.
DR   PaxDb; Q9PN86; -.
DR   PRIDE; Q9PN86; -.
DR   EnsemblBacteria; CAL35324; CAL35324; Cj1209.
DR   GeneID; 905499; -.
DR   KEGG; cje:Cj1209; -.
DR   PATRIC; fig|192222.6.peg.1191; -.
DR   eggNOG; COG1418; Bacteria.
DR   HOGENOM; CLU_028328_1_0_7; -.
DR   OMA; PHAILGM; -.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW   Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT   CHAIN           1..517
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000163768"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          207..273
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          333..426
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   517 AA;  58026 MW;  6A799602ED363A25 CRC64;
     MIESLIALIA AIVGLGIGYL VAKKINDAKY EIFVEQAKAK AKAIEYEAEL ILKDAKNSIL
     NAELEVKKKY EEKTHKFQKD FNQKFDDLSK KEQKLQQEEE KLKEDKEYLC KSQKHIQNLQ
     SDVDKLKNKY QEKLDDVLKI LEHSTGLTQN EAKEIILKKV EENSREQIAH IVRKYEEEAK
     NEAKRKANFI IAQATSRFAG EFAAERLINV INIKNDELKG RIIGKEGRNV KTLEMVLGVD
     IIIDDTPGAI IVSCFNLYRR AIATKVIELL VEDGRIQPAR IEEIHEKVCK EFDSAILEEG
     ETIVMDLGLN KIHPEIVKLI GKLKYRASYG QNALAHSLEV AHLAGIIAAE CGGDENLARR
     AGILHDIGKA LTHDFEGSHV DLGAELCKRY KEHPVVINAI YAHHGHEEAT SIESAAVCAA
     DTLSAARPGA RREVLEAFLK RVSELEDIAK SKEGIKNAYA INAGREIRVI ANAQLVNDDE
     SVLLAKEIAA EIQEKMQYPG EIKVNVIREL RAVEYAK