RNY_CLONN
ID RNY_CLONN Reviewed; 504 AA.
AC A0Q0P3;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=NT01CX_2122;
OS Clostridium novyi (strain NT).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=386415;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NT;
RX PubMed=17115055; DOI=10.1038/nbt1256;
RA Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X.,
RA Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B.,
RA Zhou S.;
RT "The genome and transcriptomes of the anti-tumor agent Clostridium novyi-
RT NT.";
RL Nat. Biotechnol. 24:1573-1580(2006).
CC -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC {ECO:0000255|HAMAP-Rule:MF_00335}.
CC -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC Rule:MF_00335}.
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DR EMBL; CP000382; ABK62001.1; -; Genomic_DNA.
DR RefSeq; WP_011722195.1; NC_008593.1.
DR AlphaFoldDB; A0Q0P3; -.
DR STRING; 386415.NT01CX_2122; -.
DR EnsemblBacteria; ABK62001; ABK62001; NT01CX_2122.
DR KEGG; cno:NT01CX_2122; -.
DR PATRIC; fig|386415.7.peg.1227; -.
DR eggNOG; COG1418; Bacteria.
DR HOGENOM; CLU_028328_1_0_9; -.
DR OMA; PHAILGM; -.
DR Proteomes; UP000008220; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 3.30.1370.10; -; 1.
DR HAMAP; MF_00335; RNase_Y; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR017705; Ribonuclease_Y.
DR InterPro; IPR022711; RNase_Y_N.
DR PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF12072; RNase_Y_N; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; SSF54791; 1.
DR TIGRFAMs; TIGR00277; HDIG; 1.
DR TIGRFAMs; TIGR03319; RNase_Y; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 3: Inferred from homology;
KW Endonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding.
FT CHAIN 1..504
FT /note="Ribonuclease Y"
FT /id="PRO_0000344852"
FT DOMAIN 194..279
FT /note="KH"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT DOMAIN 320..413
FT /note="HD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ SEQUENCE 504 AA; 57178 MW; 09009E51E81A7683 CRC64;
MIITILIAIF VIIYVRKNIS QAKIAEAEAK SKKIIIDSEK NAEAIKKEAI LEAKEEVHRI
RNDFEKESRE RRNEIQRLER RIIQREELLD KKSEAIENKE EVLNKKQQDI NEKAASIDEL
YDKQREELEK LSNLSSDEAR ELLLEETKKE IRHDLAVMIK EMENKAKEEA DKKAKEIIST
AIQRCAADHV AESTVHVVSL PNDEMKGRII GREGRNIRAL ETLTGVDLII DDTPEAVILS
GFDPIRRQVA RIALEKLIID GRIHPARIEE MVEKAKQEVE NDIKEEGEQA TFETGVHGLH
QELVKLLGRL KYRTSYGQNV LKHSMEVAYL AGLMASELGM DPTLAKRSGL LHDIGKAVDH
EIEGPHALIG SEMAKKYHES SVVVNAIAAH HGDVEYESIE AILVQAADAI SAARPGARRE
TLEAYIKRLE KLEEIANSYE GVEKSYAIQA GREVRIMVKP EDIDDYGCIE MSKNIVKRIE
SELEYPGQIK VNIIREVRAV EYAK
