RNY_DEIRA
ID RNY_DEIRA Reviewed; 572 AA.
AC Q9RRM6;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=DR_2462;
OS Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=243230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT R1.";
RL Science 286:1571-1577(1999).
CC -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC {ECO:0000255|HAMAP-Rule:MF_00335}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC Rule:MF_00335}.
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DR EMBL; AE000513; AAF12001.1; -; Genomic_DNA.
DR PIR; H75271; H75271.
DR RefSeq; NP_296182.1; NC_001263.1.
DR RefSeq; WP_010889087.1; NC_001263.1.
DR AlphaFoldDB; Q9RRM6; -.
DR SMR; Q9RRM6; -.
DR STRING; 243230.DR_2462; -.
DR EnsemblBacteria; AAF12001; AAF12001; DR_2462.
DR KEGG; dra:DR_2462; -.
DR PATRIC; fig|243230.17.peg.2698; -.
DR eggNOG; COG1418; Bacteria.
DR eggNOG; COG2433; Bacteria.
DR HOGENOM; CLU_028328_1_0_0; -.
DR InParanoid; Q9RRM6; -.
DR OMA; PHAILGM; -.
DR OrthoDB; 1012190at2; -.
DR Proteomes; UP000002524; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00077; HDc; 1.
DR HAMAP; MF_00335; RNase_Y; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR017705; Ribonuclease_Y.
DR InterPro; IPR022711; RNase_Y_N.
DR PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF12072; RNase_Y_N; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; SSF54791; 1.
DR TIGRFAMs; TIGR00277; HDIG; 1.
DR TIGRFAMs; TIGR03319; RNase_Y; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT CHAIN 1..572
FT /note="Ribonuclease Y"
FT /id="PRO_0000163772"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT DOMAIN 262..322
FT /note="KH"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT DOMAIN 388..481
FT /note="HD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
FT REGION 59..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 63513 MW; F535046C94E15D3B CRC64;
MPTLYVILSL LLGLIGGVLV QRAIGSRQQA VTDDRLQREA QAEAQQIRAE AQRHARELHE
AAEQDRQDAI SKTQDAARRV QDAAERDTLA AAHEARLDEQ REQVRALRAQ LEAEREQAKA
DAAQQREALS TDRQETRRER EDLGREIERL GRRTEQLDAR SDKLDALEER LEGGWREVQR
QEQEVAERLR QADLKLYEVA GLTPEVAREQ ILGRLNAELE EEKAIRVKAM TEKAGAEARR
SARSIIAQAI QRSASETSAQ LSVSVVPIPS DAMKGRLIGR EGRNIRAFES LTGVDLIIDD
TPEAVILSSF NPLRREVARH VLDALVADGR IHPTRIEEMV HKAQDDMKTF IHQQGEEAAI
EAGVVGLKPG LVQLLGRMYF RTSYSQNVLK HSVQVAHLTG IMADELGLDA ALARRAGLMH
DVGKSIDREI EGTHVEIGIN LARRFGEPAE VIDAIAHHHD PENGETLYSV LVAAADAISA
ARPGARREAL ESYVRRLEQL EQIAVAFPGV QQAYAIQAGR EVRVIVQPEK VTDAQATLLA
RDIAGRVEQD MEYPGQVQVT VVRESRAVGV AR
