ID   RNY_FRAAA               Reviewed;         725 AA.
AC   Q0RDW7;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=FRAAL5717;
OS   Frankia alni (strain ACN14a).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=326424;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACN14a;
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA   Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA   Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA   Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA   Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA   Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA   Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; CT573213; CAJ64349.1; -; Genomic_DNA.
DR   RefSeq; WP_011606791.1; NC_008278.1.
DR   AlphaFoldDB; Q0RDW7; -.
DR   STRING; 326424.FRAAL5717; -.
DR   KEGG; fal:FRAAL5717; -.
DR   eggNOG; COG1418; Bacteria.
DR   HOGENOM; CLU_028328_1_0_11; -.
DR   OMA; GISEMHP; -.
DR   OrthoDB; 1012190at2; -.
DR   Proteomes; UP000000657; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW   Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT   CHAIN           1..725
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000344876"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          415..481
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          541..634
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
FT   REGION          62..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          165..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   725 AA;  77751 MW;  EE3C92153C61677A CRC64;
     MDGVLVILLS LVLLVLVALI LAVAWLARTA RGDRHYGAAT RATRSSSGMA ASVDALALDD
     DDGPAVRVLP PVRPAAEGER PAGDAPGAAY GESAAAPDAG LGSPAPRAPH HDAAAAPEPG
     AAIGGAPTPA AGSPADASDT GRIAETVDTG TVLAVAAVAD TPSRVAATED TSLEAPLRES
     ALRESAPGES ASVRRAAERE AAQIVARAER EAAERLARVE REAAEIRRRG EDEVASLRNQ
     ARAEAAADAS RAEAAVRDAA RVELEAARAE IATARTSFEE ELRVRRAELR GREEALAARE
     QRVEERTAGL DEHASRLAGR EQDLLDREDE LAHRTAEAAD DEAARQAALE RIAELTAVQA
     RAELVSTIEH EARREAALLV REIEARAEEE GEERARRIVT TAIQRVASDQ TTESVVTVLH
     LPGDEMKGRI IGREGRNIRT FESVTGVNVL IDDTPEAVLL SCFDPVRREI GRITLAALVS
     DGRIHPHRIE EEYARAQVEV EERCVRAGED ALLETGISEM HPELVTLLGR LRYRTSYGQN
     VLAHLIESAH LAGIMAAELR MALPLAKRAA LLHDLGKALT HEVEGSHALI GADVARRYGE
     SEEVVHAIEA HHNEVAPRSL CAVLTQAADQ ISGGRPGARR DSLESYVKRL ERIEQIAGDR
     PGVDRVFAMQ AGREVRVMVV PEEVDDVAAH LLARDVARQI EDELTYPGQI RVTVVRETRA
     VGTAR