ID   RNY_FUSNN               Reviewed;         508 AA.
AC   Q8RHT2;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=FN1913;
OS   Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS   BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX   NCBI_TaxID=190304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC   2640 / LMG 13131 / VPI 4355;
RX   PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA   Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA   Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA   Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA   Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA   Overbeek R.;
RT   "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT   strain ATCC 25586.";
RL   J. Bacteriol. 184:2005-2018(2002).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; AE009951; AAL94012.1; -; Genomic_DNA.
DR   RefSeq; NP_602713.1; NC_003454.1.
DR   AlphaFoldDB; Q8RHT2; -.
DR   SMR; Q8RHT2; -.
DR   STRING; 190304.FN1913; -.
DR   EnsemblBacteria; AAL94012; AAL94012; FN1913.
DR   KEGG; fnu:FN1913; -.
DR   PATRIC; fig|190304.8.peg.388; -.
DR   eggNOG; COG1418; Bacteria.
DR   HOGENOM; CLU_028328_1_0_0; -.
DR   InParanoid; Q8RHT2; -.
DR   OMA; PHAILGM; -.
DR   BioCyc; FNUC190304:G1FZS-407-MON; -.
DR   Proteomes; UP000002521; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding.
FT   CHAIN           1..508
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000163773"
FT   DOMAIN          198..264
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          324..417
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   508 AA;  57224 MW;  B0F6B35CC967902F CRC64;
     MALIFAVFFK KIVIDRQIEK LNDLEDEVEK AKLKAKEIVE EAERDAVSKA KEIELKAKEK
     AYQIKEEIEK EARNSKNEIA QKEARIIKKE EILDGKIEKI EIKSLELEKI NDELEEKRKE
     IDDLRVKQEE ELSRVSELTK ADAREILLRK VREEMTHDMA ITIREFENKL DEEKEKISQK
     ILSTAIGKAA ADYVADATVS VINLPNDEMK GRIIGREGRN IRTIEALTGV DVIIDDTPEA
     VVLSCFDGVK REVARLTIEK LITDGRIHPG KIEEIVNKCK KDIEKEIVAA GEEALIELSI
     PTMHPEIIKT LGRLKYRTSY GQNVLTHSIE VAKIASTMAA EIGANVELAK RGGLLHDIGK
     VLVNEIETSH AIVGGEFIKK FGEKQDVINA VMAHHNEVEF ETVEAILVQA ADAVSASRPG
     ARRETLTAYI KRLENLEEIA NSFEGVESSY AIQAGRELRI VINPDKVSDD EATLMSREVA
     KKIEDTMQYP GQIKVTILRE TRAVEYAK