ID   RNY_HELAH               Reviewed;         529 AA.
AC   Q17Y14;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=Hac_0656;
OS   Helicobacter acinonychis (strain Sheeba).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=382638;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sheeba;
RX   PubMed=16789826; DOI=10.1371/journal.pgen.0020120;
RA   Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G.,
RA   Gressmann H., Achtman M., Schuster S.C.;
RT   "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a
RT   host jump from early humans to large felines.";
RL   PLoS Genet. 2:1097-1110(2006).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAJ99462.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AM260522; CAJ99462.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q17Y14; -.
DR   SMR; Q17Y14; -.
DR   STRING; 382638.Hac_0656; -.
DR   EnsemblBacteria; CAJ99462; CAJ99462; Hac_0656.
DR   KEGG; hac:Hac_0656; -.
DR   eggNOG; COG1418; Bacteria.
DR   HOGENOM; CLU_028328_1_0_7; -.
DR   BioCyc; HACI382638:HAC_RS02875-MON; -.
DR   Proteomes; UP000000775; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease; RNA-binding;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..529
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000344884"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          216..297
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          342..435
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   529 AA;  60301 MW;  3D2302B76D443EBC CRC64;
     MGNGLIYISL EVIVACLISA LAMYYVMKKI YYARGQAVLK SASAKAKLME FQAKSFVEAE
     EMRMKSQECK LQQQYENKNL QLKAHFDKKE AYLKHLEAQH KEFVRDEKRY LEKEKQELEK
     ERQILEQEKE NFKKQYATCK ENQSKALDVM LNYMAYTKEE IKSMILKQLE EELEAQKSAL
     IRRYEKEAKE ESKKKSYAIL AEATARFAGN YAIENFTNRI ALPCSEYIGR VIGKDGKNIE
     AFKKISGVDI EFSEGDKELC LSSFNIFRRE VASETLKILI EDGRIQPNRI EEVYHRVVRN
     MEKELLSEGQ SVVLELELGA MEDELKILLG KMRYRSSFGQ NALQHSKEVA LLAGLIAEQL
     GGDKKLARRA GILHDIGKAL TQELGRDHVS LGVEVCKRNK EDPVVINAIY AHHGHEEIMS
     IECASVCAAD ALSAGRPGAR RKSDEEYAKR MQALEEIALG FEGVEKAYAM ESGRELRVIV
     KSNQVRDNQV PIIARKIAKK IEESAQYVGE VGVQVVRESR FKTTATLKQ