RNY_HELPY
ID RNY_HELPY Reviewed; 529 AA.
AC O25455;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 2.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=HP_0760;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC {ECO:0000255|HAMAP-Rule:MF_00335}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC Rule:MF_00335}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD07808.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE000511; AAD07808.1; ALT_FRAME; Genomic_DNA.
DR PIR; H64614; H64614.
DR AlphaFoldDB; O25455; -.
DR SMR; O25455; -.
DR IntAct; O25455; 6.
DR MINT; O25455; -.
DR STRING; 85962.C694_03910; -.
DR PaxDb; O25455; -.
DR DNASU; 898987; -.
DR EnsemblBacteria; AAD07808; AAD07808; HP_0760.
DR KEGG; hpy:HP_0760; -.
DR PATRIC; fig|85962.47.peg.811; -.
DR eggNOG; COG1418; Bacteria.
DR OMA; PHAILGM; -.
DR PhylomeDB; O25455; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00077; HDc; 1.
DR HAMAP; MF_00335; RNase_Y; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR017705; Ribonuclease_Y.
DR InterPro; IPR022711; RNase_Y_N.
DR PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF12072; RNase_Y_N; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; SSF54791; 1.
DR TIGRFAMs; TIGR00277; HDIG; 1.
DR TIGRFAMs; TIGR03319; RNase_Y; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT CHAIN 1..529
FT /note="Ribonuclease Y"
FT /id="PRO_0000163774"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT DOMAIN 216..297
FT /note="KH"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT DOMAIN 342..435
FT /note="HD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ SEQUENCE 529 AA; 60130 MW; B6A1809B5E881123 CRC64;
MSSGLIYISL EVLVACLITA LVMYYVMKKI YYARGQATLK SASAKAKLME FQAKSFVEAE
EIRMKSQECK LQQQYENKNL QLQTHFDKKE AHLKHLEAQH KEFVRDEKRY LEKEKKELEK
ERQILEQEKE NFKKQRAVCK ESQAKALDAM LNYMAYTKDE IKSMILEQLE EELEAQKSAL
IRRYEKEAKE EGKKKSYAIL AEATARFAGN YAAENLTTRI ALPCSDYIGR VIGKDGKNIE
AFKKVSGVDI EFSEDSSELC LSSFNLYRRE VASETLKILI EDGRIQPNRI EEVYHRVARN
LEKELLSEGE SVVLELELGA MEDELKILIG KMRYRSSFGQ NALQHSKEVA LLAGLIAEQL
GGDKKLARRA GILHDIGKAL TQELGRDHVN LGVEVCKRHK EDPVVINAIY AHHGHEEILS
VECASVCAAD ALSAGRPGAR RKSDEEYAKR MQALEEIALE FDGVEKAYAM ESGRELRVIV
KSNQVRDNQV PIIARKIAKK IEESAQYVGE VGVQVVRESR FKTTATLKQ
