ID   RNY_MYCGE               Reviewed;         484 AA.
AC   P47376;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=MG130;
OS   Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS   (Mycoplasmoides genitalium).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; L43967; AAC71348.1; -; Genomic_DNA.
DR   PIR; D64214; D64214.
DR   RefSeq; WP_010869346.1; NC_000908.2.
DR   AlphaFoldDB; P47376; -.
DR   STRING; 243273.MG_130; -.
DR   PRIDE; P47376; -.
DR   EnsemblBacteria; AAC71348; AAC71348; MG_130.
DR   KEGG; mge:MG_130; -.
DR   eggNOG; COG1418; Bacteria.
DR   HOGENOM; CLU_563624_0_0_14; -.
DR   OMA; KYTIANH; -.
DR   OrthoDB; 1012190at2; -.
DR   BioCyc; MGEN243273:G1GJ2-143-MON; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW   Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT   CHAIN           1..484
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000163782"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          166..234
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          293..385
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   484 AA;  56033 MW;  82A95B1EDF6C481C CRC64;
     MNNNITNSIA QLFFNTSFFA FLFLIIIAFN LCLFAYLYFQ YRIYKKNPKK ANNFKANEYE
     KIKLLKNQNF TESNKLIATT NELNELTSQL DNILVRIINK PLAKLVNDFL DEQIKQIVKL
     DKNSSDFHSE SDNLPFYTKL FNDFHFGVDK LININIKNPL YNWVYSPSFL ISESDFRKLN
     GISGINKKLL VEKLRIEDIV FTDLNKKYEV NVLTESPIKA QKTVLTVRNI LMNDYVDNER
     IESYVQQANF FFTEHCKKIG KEILESLNIF ISSSSLHRHF GFLAFRYSFG QNVLSHSLET
     AFLTAHLAAL IELDSELSLK CGLLHDIGKS NDDNGKESHT ITGAKLAEQF QLPDDIKYTI
     ANHHNKHIDN TYCRLTQIAD KLSAARIGAR SDSSLLFKQL KDELKKIVDK TINNFHTTIL
     LGQSGRRLMI WLETKNQNQL LSNEQIIEMV EKIKAEIAKN PITNHFPIKV VIRYNFEHSF
     NTKS