ID   RNY_MYCMS               Reviewed;         509 AA.
AC   Q6MTI6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=MSC_0422;
OS   Mycoplasma mycoides subsp. mycoides SC (strain PG1).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG1;
RX   PubMed=14762060; DOI=10.1101/gr.1673304;
RA   Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J.,
RA   Johansson K.-E., Pettersson B., Uhlen M.;
RT   "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain
RT   PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP).";
RL   Genome Res. 14:221-227(2004).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; BX293980; CAE77050.1; -; Genomic_DNA.
DR   RefSeq; NP_975408.1; NC_005364.2.
DR   AlphaFoldDB; Q6MTI6; -.
DR   STRING; 272632.MSC_0422; -.
DR   EnsemblBacteria; CAE77050; CAE77050; MSC_0422.
DR   KEGG; mmy:MSC_0422; -.
DR   PATRIC; fig|272632.4.peg.460; -.
DR   eggNOG; COG1418; Bacteria.
DR   HOGENOM; CLU_028328_1_0_14; -.
DR   OMA; PHAILGM; -.
DR   Proteomes; UP000001016; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW   Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT   CHAIN           1..509
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000344910"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          199..259
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          325..418
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   509 AA;  57480 MW;  52EF273E74491C62 CRC64;
     MNDDIIILLS VFCGIFFICF IICSSIALYL WKSKSRKRLV EQYTKEAKQA KKQILANGYK
     EISEAKMLFL KRSELEKNEL DRVKEQLELR SNDLKRNQEI VESKSQRLDA SLLDLEKRKF
     LLDKKEEYLI KILEDASGLT KSQAKELLIK QVKNKSEKEL ISILKNAELQ AHSSSKMIAN
     NIIISAMERI KVELTSQRTT NIVKLPSDDL KGRIIGKDGR NMKAFEQIGG VDIVVDETPN
     TVVVSSFNPI RREIATRTLE QLIIDGRIQP IKIENELKKQ EQELEYIIQE TGLSTIKELN
     INDIDIELVK LIGKLKFRTS YGQNVLAHSI EVAKLSGAIA SELGLDVEKA IRAGLLHDIG
     KAIDFEKQGS HVVLGAEIAK KYNEDPIIIN CIESHHEDKE KESEIAAIVA IADSISASRP
     GARYNAIDEF ILRMTEIEKI GNSIPGVAKT YALQSGRQIR LIVNPLVASD LDLAMILEKM
     KEEIKNKVII PGEITITVIR ERKETDVLK