ID   RNY_MYCPN               Reviewed;         493 AA.
AC   P75506;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=MPN_269;
GN   ORFNames=A65_orf493, MP564;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; U00089; AAB96212.1; -; Genomic_DNA.
DR   PIR; S73890; S73890.
DR   RefSeq; NP_109957.1; NC_000912.1.
DR   RefSeq; WP_010874626.1; NC_000912.1.
DR   AlphaFoldDB; P75506; -.
DR   IntAct; P75506; 7.
DR   STRING; 272634.MPN_269; -.
DR   EnsemblBacteria; AAB96212; AAB96212; MPN_269.
DR   KEGG; mpn:MPN_269; -.
DR   PATRIC; fig|272634.6.peg.288; -.
DR   HOGENOM; CLU_563624_0_0_14; -.
DR   OMA; KYTIANH; -.
DR   BioCyc; MPNE272634:G1GJ3-420-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW   Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT   CHAIN           1..493
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000163784"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          172..241
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          300..392
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   493 AA;  56527 MW;  E2D6DE7C8E2FE054 CRC64;
     MSAKLTLESI AKTFAETSIF AILFLIIVIL NLGLLVFLAY QYRVYKKKQR ANLTKQTYNN
     DYGQIVNLKQ QNGAKIKELA NLKDQLSELG QKFNTTLSEI INKPLVNVID EYLDEQFKQA
     ANFREAELNA VLDSNDQKTV FHKRLFNKFH FGVDKLANIN VKNPLNLCWV DSASFTVIES
     DFRKLNGVGG INKKLLIEKL RIEDIIFTNI DKKYYEVQIL SDSPVKVQKT VLTIRNILIN
     DYVDNEKIES YAREANGYFN DHCKLIGKQV LERLNIFEIS PKLHKFFGLL AFRYSFGQNV
     LSHCLETGFL TAYLALLVNF KPDVALKCGL YHDIGKADDE NGKKNHTVTG AKIGDEFYFE
     NDVKYTIANH HNKNVDNVYC RLTQIGDKLS AGRLGARSDS SVLFSQLKQE LKQIVEETLA
     QFKTTILLGQ SGRRLVIWLE TNQHNNIIDN QQLTDLATTI KSKIVQNNIT NRFPIKVVLR
     YNFEHSFDTK DKN