ID   RNY_NATTJ               Reviewed;         487 AA.
AC   B2A3V6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN   Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=Nther_1475;
OS   Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 /
OS   JW/NM-WN-LF).
OC   Bacteria; Firmicutes; Clostridia; Natranaerobiales; Natranaerobiaceae;
OC   Natranaerobius.
OX   NCBI_TaxID=457570;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.;
RT   "Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-
RT   LF.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC       {ECO:0000255|HAMAP-Rule:MF_00335}.
CC   -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC       Rule:MF_00335}.
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DR   EMBL; CP001034; ACB85058.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2A3V6; -.
DR   SMR; B2A3V6; -.
DR   STRING; 457570.Nther_1475; -.
DR   PRIDE; B2A3V6; -.
DR   EnsemblBacteria; ACB85058; ACB85058; Nther_1475.
DR   KEGG; nth:Nther_1475; -.
DR   eggNOG; COG1418; Bacteria.
DR   HOGENOM; CLU_028328_0_0_9; -.
DR   OMA; PHAILGM; -.
DR   Proteomes; UP000001683; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   HAMAP; MF_00335; RNase_Y; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR017705; Ribonuclease_Y.
DR   InterPro; IPR022711; RNase_Y_N.
DR   PANTHER; PTHR12826:SF15; PTHR12826:SF15; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF12072; RNase_Y_N; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   TIGRFAMs; TIGR03319; RNase_Y; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding.
FT   CHAIN           1..487
FT                   /note="Ribonuclease Y"
FT                   /id="PRO_0000344911"
FT   DOMAIN          177..240
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT   DOMAIN          303..396
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
FT   REGION          36..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          63..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   487 AA;  55094 MW;  51969521A6A02B77 CRC64;
     MIAEAKITSA EEAADKIIED AKKQGESMKR EALLEAKEEI HTQRNELEKE TRERRNEIQR
     FERKLEQKEE SLSKQQKQLE QKEKEIAQKD EKITNKEQEL EKIYQQQVEE LENLSGLTTQ
     EAKDMLLNRV REDISHETAM MIKEMESRAK EEADKKAREI ITTAIQRCAV DHVAESTVSV
     VSLPNDEMKG RIIGREGRNI RTLETLTGID LIIDDTPEAV ILSGFDPIRR EIARLALEKL
     VSDGRIHPAR IEEMVEKAQK EVDEQIREEG EQATLDTGVH GLHSELIKLL GRLKFRTSYG
     QNVLNHSIEV ARLCGVMAHE LGTDVNTAKR AGLLHDIGKA VDHEYEGPHV TIGAELGKKY
     GESSNVLHAI ATHHGDEEPE TIEAVLVQAA DAISAARPGA RRETLESYIK RLEKLEEIAD
     SYKSVEKAYA IQAGREVRIM VKPEQADDET SINLARDISK QIEAELDYPG QIKITVIRET
     RAVEYAK